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Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma

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  1. Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis

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  2. Use of Healthcare Services Two Years before Diagnosis in Danish Sarcoma Patients, 2000-2013

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  3. A Phase I/II Clinical Trial of Belinostat (PXD101) in Combination with Doxorubicin in Patients with Soft Tissue Sarcomas

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  4. Metastatic pattern, local relapse, and survival of patients with myxoid liposarcoma: a retrospective study of 45 patients

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  5. Vascularized fibula grafts for reconstruction of bone defects after resection of bone sarcomas

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  1. Colorectal cancer in adolescents and young adults with Lynch syndrome: a Danish register-based study

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  2. Lynch syndrome-associated epithelial ovarian cancer and its immunological profile

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  3. Timely treatment initiation; a reminder about effort to reduce system-related lead times

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  • Josefin Fernebro
  • Ana Carneiro
  • Anders Rydholm
  • Henryk A Domanski
  • Anna Karlsson
  • Ake Borg
  • Mef Nilbert
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Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant subtype. Results. aCGH profiling revealed genetic complexity with multiple gains and losses in all tumors. In an unsupervised hierarchical cluster analysis, similar genomic profiles and close clustering between the first and subsequent STS were identified in 5 cases, suggesting metastatic disease, whereas the tumors from the remaining 8 patients did not cluster and showed only weak pairwise correlation, suggesting development of second primary STS. Discussion. The similarities and dissimilarities identified in the first and second STS suggest that genetic profiles can be used to distinguish soft tissue metastases from second primary STS. The demonstration of genetically different soft tissue sarcomas in the same patient suggests independent tumor origin and serves as a reminder to consider development of second primary STS, which has prognostic and therapeutic implications.
Original languageEnglish
JournalSarcoma
Volume2008
Pages (from-to)431019
ISSN1357-714X
DOIs
Publication statusPublished - 2009

ID: 32548845