Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Genetic predisposition to long telomeres is associated with increased mortality after melanoma: A study of 2101 melanoma patients from hospital clinics and the general population

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Midkine-A potential therapeutic target in melanoma

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. A novel LC-MS/MS method to quantify eumelanin and pheomelanin and their relation to UVR sensitivity - A study on human skin biopsies

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Germline variants in oculocutaneous albinism genes and predisposition to familial cutaneous melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features and clinical outcome

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Genetics of familial melanoma: 20 years after CDKN2A

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Whether there is an association between measured and genetically predicted telomere length and melanoma mortality is unclear. We tested the hypothesis that measured and genetically predicted telomere length is associated with mortality after a melanoma diagnosis. We followed 2,101 patients with melanoma from hospital clinics and the general population for risk of death for up to 26 years. All had telomere length measured in DNA from leukocytes, and 2052 of these were genotyped for the three single nucleotide polymorphisms rs7726159 (TERT), rs1317082 (TERC), and rs2487999 (OBFC1); all three genotypes are associated with telomere length and combined into an allele count from 0 to 6. For each telomere-lengthening allele, the hazard ratios (HRs) for mortality in the age-adjusted and multivariable-adjusted Cox analysis were 1.12 (95% confidence interval: 1.02–1.23) and 1.11 (1.01–1.23). However, for each standard deviation increase in measured telomere length, HR for mortality was 0.97 (0.88–1.08). In conclusion, in more than 2000 melanoma patients from hospital clinics and from the general population, genetically predicted long telomeres were associated with increased mortality, but measured leukocyte telomere length was not.

Original languageEnglish
JournalPigment Cell and Melanoma Research
Volume34
Issue number5
Pages (from-to)946-954
Number of pages9
ISSN1755-1471
DOIs
Publication statusPublished - Sep 2021

    Research areas

  • biomarkers, melanoma, mortality, survival, telomere homeostasis

ID: 66501637