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Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

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Aasbrenn, M, Svendstrup, M, Schnurr, TM, Lindqvist Hansen, D, Worm, D, Balslev-Harder, M, Grarup, N, Burgdorf, KS, Vestergaard, H, Pedersen, O, Ängquist, L, Fenger, M, Sørensen, TIA, Madsbad, S & Hansen, T 2021, 'Genetic markers of abdominal obesity and weight loss after gastric bypass surgery', PLoS One, vol. 16, no. 5, e0252525, pp. e0252525. https://doi.org/10.1371/journal.pone.0252525

APA

Aasbrenn, M., Svendstrup, M., Schnurr, T. M., Lindqvist Hansen, D., Worm, D., Balslev-Harder, M., Grarup, N., Burgdorf, K. S., Vestergaard, H., Pedersen, O., Ängquist, L., Fenger, M., Sørensen, T. I. A., Madsbad, S., & Hansen, T. (2021). Genetic markers of abdominal obesity and weight loss after gastric bypass surgery. PLoS One, 16(5), e0252525. [e0252525]. https://doi.org/10.1371/journal.pone.0252525

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Aasbrenn, Martin ; Svendstrup, Mathilde ; Schnurr, Theresia M ; Lindqvist Hansen, Dorte ; Worm, Dorte ; Balslev-Harder, Marie ; Grarup, Niels ; Burgdorf, Kristoffer Sølvsten ; Vestergaard, Henrik ; Pedersen, Oluf ; Ängquist, Lars ; Fenger, Mogens ; Sørensen, Thorkild I A ; Madsbad, Sten ; Hansen, Torben. / Genetic markers of abdominal obesity and weight loss after gastric bypass surgery. In: PLoS One. 2021 ; Vol. 16, No. 5. pp. e0252525.

Bibtex

@article{6fe4fc22ce274fbcaab9b149deb9da0a,
title = "Genetic markers of abdominal obesity and weight loss after gastric bypass surgery",
abstract = "BACKGROUND: Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.METHODS: Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.RESULTS: The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).DISCUSSION: GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.",
author = "Martin Aasbrenn and Mathilde Svendstrup and Schnurr, {Theresia M} and {Lindqvist Hansen}, Dorte and Dorte Worm and Marie Balslev-Harder and Niels Grarup and Burgdorf, {Kristoffer S{\o}lvsten} and Henrik Vestergaard and Oluf Pedersen and Lars {\"A}ngquist and Mogens Fenger and S{\o}rensen, {Thorkild I A} and Sten Madsbad and Torben Hansen",
note = "Publisher Copyright: {\textcopyright} 2021 Aasbrenn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = may,
day = "28",
doi = "10.1371/journal.pone.0252525",
language = "English",
volume = "16",
pages = "e0252525",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

AU - Aasbrenn, Martin

AU - Svendstrup, Mathilde

AU - Schnurr, Theresia M

AU - Lindqvist Hansen, Dorte

AU - Worm, Dorte

AU - Balslev-Harder, Marie

AU - Grarup, Niels

AU - Burgdorf, Kristoffer Sølvsten

AU - Vestergaard, Henrik

AU - Pedersen, Oluf

AU - Ängquist, Lars

AU - Fenger, Mogens

AU - Sørensen, Thorkild I A

AU - Madsbad, Sten

AU - Hansen, Torben

N1 - Publisher Copyright: © 2021 Aasbrenn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/28

Y1 - 2021/5/28

N2 - BACKGROUND: Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.METHODS: Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.RESULTS: The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).DISCUSSION: GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.

AB - BACKGROUND: Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, genetic determinants of abdominal obesity have been shown to attenuate weight loss after dietary intervention with special attention paid to the rs1358980-T risk allele in the VEGFA locus. Here we aimed to test if updated genetic risk scores (GRSs) for adiposity measures and the rs1358980-T risk allele are linked with weight loss following gastric bypass surgery.METHODS: Five hundred seventy six patients with morbid obesity underwent Roux-en-Y gastric bypass. A GRS for BMI and a GRS for waist-hip-ratio adjusted for BMI (proxy for abdominal obesity), respectively, were constructed. All patients were genotyped for the rs1358980-T risk allele. Associations between the genetic determinants and weight loss after bariatric surgery were evaluated.RESULTS: The GRS for BMI was not associated with weight loss (β = -2.0 kg/100 risk alleles, 95% CI -7.5 to 3.3, p = 0.45). Even though the GRS for abdominal obesity was associated with an attenuated weight loss response adjusted for age, sex and center (β = -14.6 kg/100 risk alleles, 95% CI -25.4 to -3.8, p = 0.008), it was not significantly associated with weight loss after adjustment for baseline BMI (β = -7.9 kg/100 risk alleles, 95% CI -17.5 to 1.6, p = 0.11). Similarly, the rs1358980-T risk allele was not significantly associated with weight loss (β = -0.8 kg/risk allele, 95% CI -2.2 to 0.6, p = 0.25).DISCUSSION: GRSs for adiposity derived from large meta-analyses and the rs1358980-T risk allele in the VEGFA locus did not predict weight loss after gastric bypass surgery. The association between a GRS for abdominal obesity and the response to bariatric surgery may be dependent on the association between the GRS and baseline BMI.

UR - http://www.scopus.com/inward/record.url?scp=85106753557&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0252525

DO - 10.1371/journal.pone.0252525

M3 - Journal article

C2 - 34048505

VL - 16

SP - e0252525

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 5

M1 - e0252525

ER -

ID: 65944144