Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Genetic liability to ADHD and substance use disorders in individuals with ADHD

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wimberley, T, Agerbo, E, Horsdal, HT, Ottosen, C, Brikell, I, Als, TD, Demontis, D, Børglum, AD, Nordentoft, M, Mors, O, Werge, T, Hougaard, D, Bybjerg-Grauholm, J, Hansen, MB, Mortensen, PB, Thapar, A, Riglin, L, Langley, K & Dalsgaard, S 2019, 'Genetic liability to ADHD and substance use disorders in individuals with ADHD' Addiction (Abingdon, England). https://doi.org/10.1111/add.14910

APA

Wimberley, T., Agerbo, E., Horsdal, H. T., Ottosen, C., Brikell, I., Als, T. D., ... Dalsgaard, S. (2019). Genetic liability to ADHD and substance use disorders in individuals with ADHD. Addiction (Abingdon, England). https://doi.org/10.1111/add.14910

CBE

Wimberley T, Agerbo E, Horsdal HT, Ottosen C, Brikell I, Als TD, Demontis D, Børglum AD, Nordentoft M, Mors O, Werge T, Hougaard D, Bybjerg-Grauholm J, Hansen MB, Mortensen PB, Thapar A, Riglin L, Langley K, Dalsgaard S. 2019. Genetic liability to ADHD and substance use disorders in individuals with ADHD. Addiction (Abingdon, England). https://doi.org/10.1111/add.14910

MLA

Vancouver

Author

Wimberley, Theresa ; Agerbo, Esben ; Horsdal, Henriette Thisted ; Ottosen, Caecilie ; Brikell, Isabell ; Als, Thomas Damm ; Demontis, Ditte ; Børglum, Anders D ; Nordentoft, Merete ; Mors, Ole ; Werge, Thomas ; Hougaard, David ; Bybjerg-Grauholm, Jonas ; Hansen, Marie Baekvad ; Mortensen, Preben Bo ; Thapar, Anita ; Riglin, Lucy ; Langley, Kate ; Dalsgaard, Søren. / Genetic liability to ADHD and substance use disorders in individuals with ADHD. In: Addiction (Abingdon, England). 2019.

Bibtex

@article{071c1542122949c5aa9557fde3f759b7,
title = "Genetic liability to ADHD and substance use disorders in individuals with ADHD",
abstract = "AIMS: 1) To investigate whether genetic liability to attention-deficit/hyperactivity disorder (ADHD), indexed by polygenic risk scores for ADHD (PRS-ADHD), is associated with substance use disorders (SUD) in individuals with ADHD. 2) To investigate whether other individual- or family-related risk factors for SUD could mediate or confound this association.DESIGN: Population-based cohort study SETTING AND PARTICIPANTS: ADHD cases in the iPSYCH sample (a Danish case-cohort sample of genotyped cases with specific mental disorders), born in Denmark between 1981 and 2003 (N = 13 116). Register-based information on hospital diagnoses of SUD was available until December 31, 2016.MEASUREMENTS: We estimated odds ratios (ORs) with 95{\%} confidence intervals (CIs) for any SUD as well as for different SUD types (alcohol, cannabis, and other illicit drugs) and severities (use, abuse, and addiction), with effect sizes corresponding to a comparison of the highest PRS-ADHD decile to the lowest.FINDINGS: PRS-ADHD were associated with any SUD (OR = 1.30, 95{\%} CI: 1.11-1.51). Estimates were similar across different types and severity levels of SUD. Other risk factors for SUD (male sex, age at ADHD diagnosis, comorbid conduct problems, and parental factors including SUD, mental disorders, and socio-economic status) were independently associated with increased risk of SUD. PRS-ADHD explained a minor proportion of the variance in SUD (0.2{\%} on the liability scale) compared to the other risk factors. The association between PRS-ADHD and any SUD was slightly attenuated (OR = 1.21, 95{\%} CI: 1.03-1.41) after adjusting for the other risk factors for SUD. Furthermore, associations were nominally higher in females than in males (ORfemales = 1.59, 95{\%} CI: 1.19-2.12, ORmales = 1.18, 95{\%} CI: 0.98-1.42).CONCLUSIONS: A higher genetic liability to attention-deficit/hyperactivity disorder appears to be associated with higher risks of substance use disorders in individuals with attention-deficit/hyperactivity disorder.",
author = "Theresa Wimberley and Esben Agerbo and Horsdal, {Henriette Thisted} and Caecilie Ottosen and Isabell Brikell and Als, {Thomas Damm} and Ditte Demontis and B{\o}rglum, {Anders D} and Merete Nordentoft and Ole Mors and Thomas Werge and David Hougaard and Jonas Bybjerg-Grauholm and Hansen, {Marie Baekvad} and Mortensen, {Preben Bo} and Anita Thapar and Lucy Riglin and Kate Langley and S{\o}ren Dalsgaard",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "12",
day = "5",
doi = "10.1111/add.14910",
language = "English",
journal = "Addiction",
issn = "0965-2140",
publisher = "Wiley-Blackwell Publishing Ltd",

}

RIS

TY - JOUR

T1 - Genetic liability to ADHD and substance use disorders in individuals with ADHD

AU - Wimberley, Theresa

AU - Agerbo, Esben

AU - Horsdal, Henriette Thisted

AU - Ottosen, Caecilie

AU - Brikell, Isabell

AU - Als, Thomas Damm

AU - Demontis, Ditte

AU - Børglum, Anders D

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Werge, Thomas

AU - Hougaard, David

AU - Bybjerg-Grauholm, Jonas

AU - Hansen, Marie Baekvad

AU - Mortensen, Preben Bo

AU - Thapar, Anita

AU - Riglin, Lucy

AU - Langley, Kate

AU - Dalsgaard, Søren

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/12/5

Y1 - 2019/12/5

N2 - AIMS: 1) To investigate whether genetic liability to attention-deficit/hyperactivity disorder (ADHD), indexed by polygenic risk scores for ADHD (PRS-ADHD), is associated with substance use disorders (SUD) in individuals with ADHD. 2) To investigate whether other individual- or family-related risk factors for SUD could mediate or confound this association.DESIGN: Population-based cohort study SETTING AND PARTICIPANTS: ADHD cases in the iPSYCH sample (a Danish case-cohort sample of genotyped cases with specific mental disorders), born in Denmark between 1981 and 2003 (N = 13 116). Register-based information on hospital diagnoses of SUD was available until December 31, 2016.MEASUREMENTS: We estimated odds ratios (ORs) with 95% confidence intervals (CIs) for any SUD as well as for different SUD types (alcohol, cannabis, and other illicit drugs) and severities (use, abuse, and addiction), with effect sizes corresponding to a comparison of the highest PRS-ADHD decile to the lowest.FINDINGS: PRS-ADHD were associated with any SUD (OR = 1.30, 95% CI: 1.11-1.51). Estimates were similar across different types and severity levels of SUD. Other risk factors for SUD (male sex, age at ADHD diagnosis, comorbid conduct problems, and parental factors including SUD, mental disorders, and socio-economic status) were independently associated with increased risk of SUD. PRS-ADHD explained a minor proportion of the variance in SUD (0.2% on the liability scale) compared to the other risk factors. The association between PRS-ADHD and any SUD was slightly attenuated (OR = 1.21, 95% CI: 1.03-1.41) after adjusting for the other risk factors for SUD. Furthermore, associations were nominally higher in females than in males (ORfemales = 1.59, 95% CI: 1.19-2.12, ORmales = 1.18, 95% CI: 0.98-1.42).CONCLUSIONS: A higher genetic liability to attention-deficit/hyperactivity disorder appears to be associated with higher risks of substance use disorders in individuals with attention-deficit/hyperactivity disorder.

AB - AIMS: 1) To investigate whether genetic liability to attention-deficit/hyperactivity disorder (ADHD), indexed by polygenic risk scores for ADHD (PRS-ADHD), is associated with substance use disorders (SUD) in individuals with ADHD. 2) To investigate whether other individual- or family-related risk factors for SUD could mediate or confound this association.DESIGN: Population-based cohort study SETTING AND PARTICIPANTS: ADHD cases in the iPSYCH sample (a Danish case-cohort sample of genotyped cases with specific mental disorders), born in Denmark between 1981 and 2003 (N = 13 116). Register-based information on hospital diagnoses of SUD was available until December 31, 2016.MEASUREMENTS: We estimated odds ratios (ORs) with 95% confidence intervals (CIs) for any SUD as well as for different SUD types (alcohol, cannabis, and other illicit drugs) and severities (use, abuse, and addiction), with effect sizes corresponding to a comparison of the highest PRS-ADHD decile to the lowest.FINDINGS: PRS-ADHD were associated with any SUD (OR = 1.30, 95% CI: 1.11-1.51). Estimates were similar across different types and severity levels of SUD. Other risk factors for SUD (male sex, age at ADHD diagnosis, comorbid conduct problems, and parental factors including SUD, mental disorders, and socio-economic status) were independently associated with increased risk of SUD. PRS-ADHD explained a minor proportion of the variance in SUD (0.2% on the liability scale) compared to the other risk factors. The association between PRS-ADHD and any SUD was slightly attenuated (OR = 1.21, 95% CI: 1.03-1.41) after adjusting for the other risk factors for SUD. Furthermore, associations were nominally higher in females than in males (ORfemales = 1.59, 95% CI: 1.19-2.12, ORmales = 1.18, 95% CI: 0.98-1.42).CONCLUSIONS: A higher genetic liability to attention-deficit/hyperactivity disorder appears to be associated with higher risks of substance use disorders in individuals with attention-deficit/hyperactivity disorder.

U2 - 10.1111/add.14910

DO - 10.1111/add.14910

M3 - Journal article

JO - Addiction

JF - Addiction

SN - 0965-2140

ER -

ID: 58541042