Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium & 23andMe Research Team 2020, 'Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease', Nature Genetics, vol. 52, no. 5, pp. 482-493. https://doi.org/10.1038/s41588-020-0610-9

APA

Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, & 23andMe Research Team (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics, 52(5), 482-493. https://doi.org/10.1038/s41588-020-0610-9

CBE

Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, 23andMe Research Team. 2020. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics. 52(5):482-493. https://doi.org/10.1038/s41588-020-0610-9

MLA

Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium and 23andMe Research Team. "Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease". Nature Genetics. 2020, 52(5). 482-493. https://doi.org/10.1038/s41588-020-0610-9

Vancouver

Eating Disorders Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, 23andMe Research Team. Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics. 2020 May;52(5):482-493. https://doi.org/10.1038/s41588-020-0610-9

Author

Eating Disorders Working Group of the Psychiatric Genomics Consortium ; International Headache Genetics Consortium ; 23andMe Research Team. / Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. In: Nature Genetics. 2020 ; Vol. 52, No. 5. pp. 482-493.

Bibtex

@article{9ad525d9a68648fa9da648c22d996dab,
title = "Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson{\textquoteright}s disease",
abstract = "Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson{\textquoteright}s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson{\textquoteright}s disease.",
author = "Julien Bryois and Skene, {Nathan G.} and Hansen, {Thomas Folkmann} and Kogelman, {Lisette J.A.} and Watson, {Hunna J.} and Zijing Liu and Roger Adan and Lars Alfredsson and Tetsuya Ando and Ole Andreassen and Jessica Baker and Andrew Bergen and Wade Berrettini and Andreas Birgeg{\aa}rd and Joseph Boden and Ilka Boehm and Claudette Boni and {Boraska Perica}, Vesna and Harry Brandt and Gerome Breen and Julien Bryois and Katharina Buehren and Cynthia Bulik and Roland Burghardt and Matteo Cassina and Sven Cichon and Maurizio Clementi and Jonathan Coleman and Roger Cone and Philippe Courtet and Steven Crawford and Scott Crow and James Crowley and Unna Danner and Oliver Davis and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and Janiece DeSocio and Danielle Dick and Dimitris Dikeos and Christian Dina and Monika Dmitrzak-Weglarz and {Docampo Martinez}, Elisa and Laramie Duncan and Liselotte Petersen and Hansen, {Thomas Folkmann} and Andres Ingason and Kogelman, {Lisette J.A.} and Jes Olesen and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and {International Headache Genetics Consortium} and {23andMe Research Team}",
year = "2020",
month = may,
doi = "10.1038/s41588-020-0610-9",
language = "English",
volume = "52",
pages = "482--493",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

AU - Bryois, Julien

AU - Skene, Nathan G.

AU - Hansen, Thomas Folkmann

AU - Kogelman, Lisette J.A.

AU - Watson, Hunna J.

AU - Liu, Zijing

AU - Adan, Roger

AU - Alfredsson, Lars

AU - Ando, Tetsuya

AU - Andreassen, Ole

AU - Baker, Jessica

AU - Bergen, Andrew

AU - Berrettini, Wade

AU - Birgegård, Andreas

AU - Boden, Joseph

AU - Boehm, Ilka

AU - Boni, Claudette

AU - Boraska Perica, Vesna

AU - Brandt, Harry

AU - Breen, Gerome

AU - Bryois, Julien

AU - Buehren, Katharina

AU - Bulik, Cynthia

AU - Burghardt, Roland

AU - Cassina, Matteo

AU - Cichon, Sven

AU - Clementi, Maurizio

AU - Coleman, Jonathan

AU - Cone, Roger

AU - Courtet, Philippe

AU - Crawford, Steven

AU - Crow, Scott

AU - Crowley, James

AU - Danner, Unna

AU - Davis, Oliver

AU - de Zwaan, Martina

AU - Dedoussis, George

AU - Degortes, Daniela

AU - DeSocio, Janiece

AU - Dick, Danielle

AU - Dikeos, Dimitris

AU - Dina, Christian

AU - Dmitrzak-Weglarz, Monika

AU - Docampo Martinez, Elisa

AU - Duncan, Laramie

AU - Petersen, Liselotte

AU - Hansen, Thomas Folkmann

AU - Ingason, Andres

AU - Kogelman, Lisette J.A.

AU - Olesen, Jes

AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium

AU - International Headache Genetics Consortium

AU - 23andMe Research Team

PY - 2020/5

Y1 - 2020/5

N2 - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease.

AB - Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease.

UR - http://www.scopus.com/inward/record.url?scp=85084195663&partnerID=8YFLogxK

U2 - 10.1038/s41588-020-0610-9

DO - 10.1038/s41588-020-0610-9

M3 - Journal article

C2 - 32341526

AN - SCOPUS:85084195663

VL - 52

SP - 482

EP - 493

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -

ID: 59829525