Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

Christina L Wassel; Claudia Lamina; Vijay Nambi; Stefan Coassin; Kenneth J Mukamal; Santhi K Ganesh; David R Jacobs; Nora Franceschini; George J Papanicolaou; Quince Gibson; Lisa R Yanek; Pim van der Harst; Jane F Ferguson; Dana C Crawford; Lindsay L Waite; Matthew A Allison; Michael H Criqui; Mary M McDermott; Reena Mehra; L Adrienne Cupples; Shih-Jen Hwang; Susan Redline; Robert C Kaplan; Gerardo Heiss; Jerome I Rotter; Eric Boerwinkle; Herman A Taylor; Luis H Eraso; Margot Haun; Mingyao Li; Christa Meisinger; Jeffrey R O'Connell; Alan R Shuldiner; Anne Tybjærg-Hansen; Ruth Frikke-Schmidt; Barbara Kollerits; Barbara Rantner; Benjamin Dieplinger; Marietta Stadler; Thomas Mueller; Meinhard Haltmayer; Peter Klein-Weigel; Monika Summerer; H-Erich Wichmann; Folkert W Asselbergs; Gerjan Navis; Irene Mateo Leach; Kristin Brown-Gentry; Robert Goodloe; Themistocles L Assimes; Diane M Becker; John P Cooke; Devin M Absher; Jeffrey W Olin; Braxton D Mitchell; Muredach P Reilly; Emile R Mohler; Kari E North; Alexander P Reiner; Florian Kronenberg; Joanne M Murabito

doi:10.1016/j.atherosclerosis.2012.01.039

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

Christina L Wassel, Claudia Lamina, Vijay Nambi, Stefan Coassin, Kenneth J Mukamal, Santhi K Ganesh, David R Jacobs, Nora Franceschini, George J Papanicolaou, Quince Gibson, Lisa R Yanek, Pim van der Harst, Jane F Ferguson, Dana C Crawford, Lindsay L Waite, Matthew A Allison, Michael H Criqui, Mary M McDermott, Reena Mehra, L Adrienne CupplesShih-Jen Hwang, Susan Redline, Robert C Kaplan, Gerardo Heiss, Jerome I Rotter, Eric Boerwinkle, Herman A Taylor, Luis H Eraso, Margot Haun, Mingyao Li, Christa Meisinger, Jeffrey R O'Connell, Alan R Shuldiner, Anne Tybjærg-Hansen, Ruth Frikke-Schmidt, Barbara Kollerits, Barbara Rantner, Benjamin Dieplinger, Marietta Stadler, Thomas Mueller, Meinhard Haltmayer, Peter Klein-Weigel, Monika Summerer, H-Erich Wichmann, Folkert W Asselbergs, Gerjan Navis, Irene Mateo Leach, Kristin Brown-Gentry, Robert Goodloe, Themistocles L Assimes, Diane M Becker, John P Cooke, Devin M Absher, Jeffrey W Olin, Braxton D Mitchell, Muredach P Reilly, Emile R Mohler, Kari E North, Alexander P Reiner, Florian Kronenberg, Joanne M Murabito

Department of Clinical Biochemistry

27 Citations (Scopus)

Abstract

Candidate gene association studies for peripheral artery disease (PAD), including subclinical disease assessed with the ankle-brachial index (ABI), have been limited by the modest number of genes examined. We conducted a two stage meta-analysis of ∼50,000 SNPs across ∼2100 candidate genes to identify genetic variants for ABI.

Original language	English
Journal	Atherosclerosis
Volume	222
Issue number	1
Pages (from-to)	138-47
Number of pages	10
ISSN	0021-9150
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.01.039
Publication status	Published - 2012

Keywords

Adult
African Americans
Aged
Ankle Brachial Index
Aryl Hydrocarbon Hydroxylases
European Continental Ancestry Group
Female
Humans
Male
Middle Aged
Oxidoreductases, N-Demethylating
Peripheral Arterial Disease
Polymorphism, Single Nucleotide
Risk Factors
Transcription Factor 7-Like 2 Protein

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10.1016/j.atherosclerosis.2012.01.039

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Wassel, C. L., Lamina, C., Nambi, V., Coassin, S., Mukamal, K. J., Ganesh, S. K., Jacobs, D. R., Franceschini, N., Papanicolaou, G. J., Gibson, Q., Yanek, L. R., van der Harst, P., Ferguson, J. F., Crawford, D. C., Waite, L. L., Allison, M. A., Criqui, M. H., McDermott, M. M., Mehra, R., ... Murabito, J. M. (2012). Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Atherosclerosis, 222(1), 138-47. https://doi.org/10.1016/j.atherosclerosis.2012.01.039

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. / Wassel, Christina L; Lamina, Claudia; Nambi, Vijay et al.
In: Atherosclerosis, Vol. 222, No. 1, 2012, p. 138-47.

Research output: Contribution to journal › Journal article › Research › peer-review

Wassel, CL, Lamina, C, Nambi, V, Coassin, S, Mukamal, KJ, Ganesh, SK, Jacobs, DR, Franceschini, N, Papanicolaou, GJ, Gibson, Q, Yanek, LR, van der Harst, P, Ferguson, JF, Crawford, DC, Waite, LL, Allison, MA, Criqui, MH, McDermott, MM, Mehra, R, Cupples, LA, Hwang, S-J, Redline, S, Kaplan, RC, Heiss, G, Rotter, JI, Boerwinkle, E, Taylor, HA, Eraso, LH, Haun, M, Li, M, Meisinger, C, O'Connell, JR, Shuldiner, AR, Tybjærg-Hansen, A , Frikke-Schmidt, R, Kollerits, B, Rantner, B, Dieplinger, B, Stadler, M, Mueller, T, Haltmayer, M, Klein-Weigel, P, Summerer, M, Wichmann, H-E, Asselbergs, FW, Navis, G, Leach, IM, Brown-Gentry, K, Goodloe, R, Assimes, TL, Becker, DM, Cooke, JP, Absher, DM, Olin, JW, Mitchell, BD, Reilly, MP, Mohler, ER, North, KE, Reiner, AP, Kronenberg, F & Murabito, JM 2012, 'Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium', Atherosclerosis, vol. 222, no. 1, pp. 138-47. https://doi.org/10.1016/j.atherosclerosis.2012.01.039

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abstract = "Candidate gene association studies for peripheral artery disease (PAD), including subclinical disease assessed with the ankle-brachial index (ABI), have been limited by the modest number of genes examined. We conducted a two stage meta-analysis of ∼50,000 SNPs across ∼2100 candidate genes to identify genetic variants for ABI.",

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year = "2012",

doi = "10.1016/j.atherosclerosis.2012.01.039",

language = "English",

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AU - Wassel, Christina L

AU - Lamina, Claudia

AU - Nambi, Vijay

AU - Coassin, Stefan

AU - Mukamal, Kenneth J

AU - Ganesh, Santhi K

AU - Jacobs, David R

AU - Franceschini, Nora

AU - Papanicolaou, George J

AU - Gibson, Quince

AU - Yanek, Lisa R

AU - van der Harst, Pim

AU - Ferguson, Jane F

AU - Crawford, Dana C

AU - Waite, Lindsay L

AU - Allison, Matthew A

AU - Criqui, Michael H

AU - McDermott, Mary M

AU - Mehra, Reena

AU - Cupples, L Adrienne

AU - Hwang, Shih-Jen

AU - Redline, Susan

AU - Kaplan, Robert C

AU - Heiss, Gerardo

AU - Rotter, Jerome I

AU - Boerwinkle, Eric

AU - Taylor, Herman A

AU - Eraso, Luis H

AU - Haun, Margot

AU - Li, Mingyao

AU - Meisinger, Christa

AU - O'Connell, Jeffrey R

AU - Shuldiner, Alan R

AU - Tybjærg-Hansen, Anne

AU - Frikke-Schmidt, Ruth

AU - Kollerits, Barbara

AU - Rantner, Barbara

AU - Dieplinger, Benjamin

AU - Stadler, Marietta

AU - Mueller, Thomas

AU - Haltmayer, Meinhard

AU - Klein-Weigel, Peter

AU - Summerer, Monika

AU - Wichmann, H-Erich

AU - Asselbergs, Folkert W

AU - Navis, Gerjan

AU - Leach, Irene Mateo

AU - Brown-Gentry, Kristin

AU - Goodloe, Robert

AU - Assimes, Themistocles L

AU - Becker, Diane M

AU - Cooke, John P

AU - Absher, Devin M

AU - Olin, Jeffrey W

AU - Mitchell, Braxton D

AU - Reilly, Muredach P

AU - Mohler, Emile R

AU - North, Kari E

AU - Reiner, Alexander P

AU - Kronenberg, Florian

AU - Murabito, Joanne M

PY - 2012

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KW - African Americans

KW - Aged

KW - Ankle Brachial Index

KW - Aryl Hydrocarbon Hydroxylases

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Oxidoreductases, N-Demethylating

KW - Peripheral Arterial Disease

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Transcription Factor 7-Like 2 Protein

UR - https://www.scopus.com/pages/publications/84862819551

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DO - 10.1016/j.atherosclerosis.2012.01.039

M3 - Journal article

C2 - 22361517

SN - 0021-9150

VL - 222

SP - 138

EP - 147

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

Abstract

Keywords

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