Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

A Linneberg, A Gonzalez-Quintela, C Vidal, T Jørgensen, M Fenger, T Hansen, O Pedersen, Lise-Lotte Husemoen

62 Citations (Scopus)

Abstract

Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.
Original languageEnglish
JournalClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume40
Issue number1
Pages (from-to)123-30
Number of pages8
DOIs
Publication statusPublished - 1 Jan 2010

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