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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk

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  • Yaohua Yang
  • Lang Wu
  • Xiang Shu
  • Yingchang Lu
  • Xiao-Ou Shu
  • Qiuyin Cai
  • Alicia Beeghly-Fadiel
  • Bingshan Li
  • Fei Ye
  • Andrew Berchuck
  • Hoda Anton-Culver
  • Susana Banerjee
  • Javier Benitez
  • Line Bjørge
  • James D Brenton
  • Ralf Butzow
  • Ian G Campbell
  • Jenny Chang-Claude
  • Kexin Chen
  • Linda S Cook
  • Daniel W Cramer
  • Anna DeFazio
  • Joe Dennis
  • Jennifer A Doherty
  • Thilo Dork
  • Diana M Eccles
  • Digna Velez Edwards
  • Peter A Fasching
  • Renée T Fortner
  • Simon A Gayther
  • Graham G Giles
  • Rosalind M Glasspool
  • Ellen L Goode
  • Marc T Goodman
  • Jacek Gronwald
  • Holly R Harris
  • Florian Heitz
  • Michelle A T Hildebrandt
  • Estrid Høgdall
  • Claus K Høgdall
  • David G Huntsman
  • Siddhartha P Kar
  • Beth Y Karlan
  • Linda E Kelemen
  • Lambertus A Kiemeney
  • Susanne K Kjaer
  • Anita Koushik
  • Diether Lambrechts
  • Nhu D Le
  • Douglas A Levine
  • Leon F A G Massuger
  • Keitaro Matsuo
  • Taymaa May
  • Iain A McNeish
  • Usha Menon
  • Francesmary Modugno
  • Alvaro N Monteiro
  • Patricia G Moorman
  • Kirsten B Moysich
  • Roberta B Ness
  • Heli Nevanlinna
  • Håkan Olsson
  • N Charlotte Onland-Moret
  • Sue K Park
  • James Paul
  • Celeste L Pearce
  • Tanja Pejovic
  • Catherine M Phelan
  • Malcolm C Pike
  • Susan J Ramus
  • Elio Riboli
  • Cristina Rodríguez-Antona
  • Isabelle Romieu
  • Dale P Sandler
  • Joellen M Schildkraut
  • Veronica W Setiawan
  • Kang Shan
  • Nadeem Siddiqui
  • Weiva Sieh
  • Meir J Stampfer
  • Rebecca Sutphen
  • Anthony J Swerdlow
  • Lukasz Michal Szafron
  • Soo Hwang Teo
  • Shelley S Tworoger
  • Jonathan P Tyrer
  • Penelope M Webb
  • Nicolas Wentzensen
  • Emily White
  • Walter C Willett
  • Alicja Wolk
  • Yin Ling Woo
  • Anna H Wu
  • Li Yan
  • Drakoulis Yannoukakos
  • Georgia Chenevix-Trench
  • Thomas A Sellers
  • Paul D P Pharoah
  • Wei Zheng
  • Jirong Long
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DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study ( N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 × 10 -7. Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression. SIGNIFICANCE: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.

Original languageEnglish
JournalCancer Research
Volume79
Issue number3
Pages (from-to)505-517
Number of pages13
ISSN0008-5472
DOIs
Publication statusPublished - 1 Feb 2019

Bibliographical note

©2018 American Association for Cancer Research.

ID: 56087148