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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know

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Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume21
Issue number15
ISSN1661-6596
DOIs
Publication statusPublished - 23 Jul 2020

ID: 61243800