Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Genetic and environmental origins of hypospadias

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hashimoto's thyroiditis as a risk factor for thyroid cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Gut hormones in the treatment of short-bowel syndrome and intestinal failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Updates in weight loss surgery and gastrointestinal peptides

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Occupational causes of male infertility

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The physiology and timing of male puberty

    Research output: Contribution to journalReviewResearch

  1. Postnatal germ cell development in cryptorchid boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Review of injection techniques for spermatogonial stem cell transplantation

    Research output: Contribution to journalReviewResearchpeer-review

  3. Laparoscopy to Assist Surgical Decisions Related to Necrotizing Enterocolitis in Preterm Neonates

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Reply by Authors

    Research output: Contribution to journalComment/debateResearch

View graph of relations

PURPOSE OF REVIEW: The purpose of this study was to review and comment on recent original presentations dealing with genetic and environmental factors in the cause of hypospadias.

RECENT FINDINGS: The heritability is definitely high and having an affected family member is the highest identified risk factor so far. Many candidate genes and polymorphisms have been suggested for hypospadias. Some associations with hypospadias were found, and many of these were replicated inconsistently as would be expected in a complex disorder affected by both genes and environment. The consistent association of hypospadias with low birth weight, maternal hypertension, and preeclampsia suggests that placental insufficiency is a major risk factor. Maternal exposure to chemical pollutants or endocrine disruptors in high concentrations related to selected occupations or geographic areas may be additional risk factors for hypospadias, especially in genetically predisposed individuals. So far, however, no environmental chemical pollutants or endocrine disruptor with a general common impact on the risk for hypospadias in most societies has been demonstrated.

SUMMARY: A major point that should be considered regarding the action of environmental toxicants in inducing hypospadias is the cumulative effects of multiple low-dose exposures. Furthermore, interactions between genetic and environmental factors may help to explain nonreplication in genetic studies of hypospadias.

Original languageEnglish
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume21
Issue number3
Pages (from-to)227-32
Number of pages6
ISSN1752-296X
DOIs
Publication statusPublished - Jun 2014

    Research areas

  • Adult, Androgens, Chorionic Gonadotropin, Environmental Pollutants, Estrogen Receptor alpha, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Hypospadias, Infant, Newborn, Male, Maternal Exposure, Placental Insufficiency, Polymorphism, Single Nucleotide, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors

ID: 45049749