Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study

Maria Bibi Lyng; Anne-Vibeke Lænkholm; Qihua Tan; Werner Vach; Karina Hedelund Gravgaard; Ann Knoop; Henrik Jørn Ditzel

doi:10.1371/journal.pone.0054078

Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study

Maria Bibi Lyng, Anne-Vibeke Lænkholm, Qihua Tan, Werner Vach, Karina Hedelund Gravgaard, Ann Knoop, Henrik Jørn Ditzel

Department of Pathology

12 Citations (Scopus)

Abstract

Tamoxifen significantly improves outcome for estrogen receptor-positive (ER+) breast cancer, but the 15-year recurrence rate remains 30%. The aim of this study was to identify gene profiles that accurately predicted the outcome of ER+ breast cancer patients who received adjuvant Tamoxifen mono-therapy.

Original language	English
Journal	P L o S One
Volume	8
Issue number	1
Pages (from-to)	e54078
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0054078
Publication status	Published - 2013

Keywords

Aged
Breast Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Female
Humans
Middle Aged
Polymerase Chain Reaction
Proto-Oncogene Proteins c-bcl-2
Receptors, Estrogen
Tamoxifen

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abstract = "Tamoxifen significantly improves outcome for estrogen receptor-positive (ER+) breast cancer, but the 15-year recurrence rate remains 30\%. The aim of this study was to identify gene profiles that accurately predicted the outcome of ER+ breast cancer patients who received adjuvant Tamoxifen mono-therapy.",

keywords = "Aged, Breast Neoplasms, Cyclin-Dependent Kinase Inhibitor p21, Female, Humans, Middle Aged, Polymerase Chain Reaction, Proto-Oncogene Proteins c-bcl-2, Receptors, Estrogen, Tamoxifen",

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T2 - a DBCG study

AU - Lyng, Maria Bibi

AU - Lænkholm, Anne-Vibeke

AU - Tan, Qihua

AU - Vach, Werner

AU - Gravgaard, Karina Hedelund

AU - Knoop, Ann

AU - Ditzel, Henrik Jørn

PY - 2013

Y1 - 2013

N2 - Tamoxifen significantly improves outcome for estrogen receptor-positive (ER+) breast cancer, but the 15-year recurrence rate remains 30%. The aim of this study was to identify gene profiles that accurately predicted the outcome of ER+ breast cancer patients who received adjuvant Tamoxifen mono-therapy.

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KW - Aged

KW - Breast Neoplasms

KW - Cyclin-Dependent Kinase Inhibitor p21

KW - Female

KW - Humans

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Proto-Oncogene Proteins c-bcl-2

KW - Receptors, Estrogen

KW - Tamoxifen

UR - https://www.scopus.com/pages/publications/84872458265

U2 - 10.1371/journal.pone.0054078

DO - 10.1371/journal.pone.0054078

M3 - Journal article

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JO - P L o S One

JF - P L o S One

IS - 1

ER -

Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: a DBCG study

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Keywords

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