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Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors

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  • Chun-Mei Zhao
  • Yosuke Kodama
  • Arnar Flatberg
  • Vidar Beisvag
  • Bård Kulseng
  • Arne K Sandvik
  • Jens F Rehfeld
  • Duan Chen
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The stomach produces acid, which may play an important role in the regulation of bone homeostasis. The aim of this study was to reveal signaling pathways in the gastric mucosa that involve the acid secretion and possibly the bone metabolism in CCK1 and/or CCK2 receptor knockout (KO) mice. Gastric acid secretion was impaired and the ECL cell signaling pathway was inhibited in CCK2 receptor KO mice but not in CCK1 receptor KO mice. However, in CCK1+2 receptor double KO mice the acid secretion in response to pylorus ligation-induced vagal stimulation and the ECL cell pathway were partially normalized, which was associated with an up-regulated pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1). The basal part of the gastric mucosa expressed parathyroid hormone-like hormone (PTHLH) in a subpopulation of likely ECL cells (and possibly other cells) and vitamin D3 1α hydroxylase probably in trefoil peptide2-immunoreactive cells. In conclusion, mice lacking CCK receptors exhibited a functional shift from the gastrin-CCK pathways to the neuronal pathway in control of the ECL cells and eventually the acid secretion. Taking the present data together with previous findings, we suggest a possible link between gastric PTHLH and vitamin D and bone metabolism.

Original languageEnglish
JournalRegulatory Peptides
Volume192-193
Pages (from-to)35-44
Number of pages10
ISSN0167-0115
DOIs
Publication statusPublished - 28 Aug 2014

ID: 44770708