Gene expression profiles of mouse spermatogenesis during recovery from irradiation

Fozia J Shah; Masami Tanaka; John E Nielsen; Teruaki Iwamoto; Shinichi Kobayashi; Niels E Skakkebaek; Henrik Leffers; Kristian Almstrup

doi:10.1186/1477-7827-7-130

Gene expression profiles of mouse spermatogenesis during recovery from irradiation

Fozia J Shah, Masami Tanaka, John E Nielsen, Teruaki Iwamoto, Shinichi Kobayashi, Niels E Skakkebaek, Henrik Leffers, Kristian Almstrup

Department of Growth and Reproduction

16 Citations (Scopus)

Abstract

Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression.

Original language	English
Journal	Reproductive Biology and Endocrinology
Volume	7
Pages (from-to)	130
ISSN	1477-7827
DOIs	https://doi.org/10.1186/1477-7827-7-130
Publication status	Published - 1 Jan 2009

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title = "Gene expression profiles of mouse spermatogenesis during recovery from irradiation",

abstract = "Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression.",

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T1 - Gene expression profiles of mouse spermatogenesis during recovery from irradiation

AU - Shah, Fozia J

AU - Tanaka, Masami

AU - Nielsen, John E

AU - Iwamoto, Teruaki

AU - Kobayashi, Shinichi

AU - Skakkebaek, Niels E

AU - Leffers, Henrik

AU - Almstrup, Kristian

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression.

AB - Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression.

U2 - 10.1186/1477-7827-7-130

DO - 10.1186/1477-7827-7-130

M3 - Journal article

C2 - 19925657

SN - 1477-7827

VL - 7

SP - 130

JO - Reproductive Biology and Endocrinology

JF - Reproductive Biology and Endocrinology

ER -

Gene expression profiles of mouse spermatogenesis during recovery from irradiation

Abstract

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