Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding

V G Frokjaer, D Erritzoe, J. Madsen, O B Paulson, G M Knudsen

21 Citations (Scopus)

Abstract

Gender influences brain function including serotonergic neurotransmission, which may play a role in the well-known gender variations in vulnerability to mood and anxiety disorders. Even though hormonal replacement therapy in menopause is associated with globally increased cerebral 5-HT(2A) receptor binding it is not clear if gender or use of hormonal contraception exhibits associations with 5-HT(2A) receptor binding. We found no significant effect of gender on cortical 5-HT(2A) receptor binding (P=0.15, n=132). When adjusting for the personality trait neuroticism, known to be positively correlated to frontolimbic 5-HT(2A) receptor binding and to be more pronounced in women, again, the effect of gender was not significant (P=0.42, n=127). Also, the use of hormonal contraception (n=14) within the group of pre-menopausal women (total n=29) was not associated with cortical 5-HT(2A) receptor binding (P=0.31). In conclusion, neither gender, nor the use of hormonal contraception in premenopausal women was associated with cortical 5-HT(2A) receptor binding.
Original languageEnglish
JournalNeuroscience
Volume163
Issue number2
Pages (from-to)640-5
Number of pages5
DOIs
Publication statusPublished - 2009

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