Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Gastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Watching, keeping and squeezing time to lose weight: implications of time-restricted eating in daily life

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Development and validation of a food literacy instrument for school children in a Danish context

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. RYGB increases the satiating effect of intrajejunal lipid infusions in female rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Comparison of sensory-specific satiety between normal weight and overweight children

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effects of endogenous GIP in patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

In young individuals, oral free fatty acid delays gastric emptying, promotes gut hormone release, and reduces energy intake more than an isocaloric load of triglyceride does. The objective of this study was to compare the effects of the free fatty acid oleic acid (OA) and the triglyceride olive oil (OO) on gastrointestinal motility, gut hormone secretion, and energy intake in older and middle-aged healthy volunteers. In a double-blind, randomized, cross-over, study 10 older (age 83.0 ± 3.4 (mean ± SD) years) and 10 middle-aged (age 43.1 ± 8.9 years) men were examined on two occasions to evaluate the effect of isocaloric and isovolaemic loads of radiolabelled OA or OO on gastric emptying, oro-caecal transit, glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretions, and energy intake. Gastric emptying was slower in older than in middle-aged men (lipid p < 0.001, water p = 0.010), while no difference between these groups was found for oro-caecal transit. In comparison with OO, OA caused slower gastric emptying (lipid p < 0.001, water p = 0.020) and faster oro-caecal transit (p = 0.025). Postprandial secretion of GLP-1 and PYY was comparable for older and middle-aged men, as well as for OA and OO. Older men ingested less energy than middle-aged men did (p < 0.001) and their energy intake was lower after OA than OO (p = 0.002). Thus, gastric emptying of an oral lipid load is slower in older than in middle-aged men; gastric emptying is slower and oro-caecal transit faster after OA than OO in both age groups; and older men ingest less energy than middle-aged men and less energy after OA than OO.

Original languageEnglish
JournalAppetite
Volume132
Pages (from-to)18-24
Number of pages7
ISSN0195-6663
DOIs
Publication statusPublished - 1 Jan 2019

Bibliographical note

Copyright © 2018 Elsevier Ltd. All rights reserved.

    Research areas

  • Gastrointestinal motility, Gut hormones, Older men, Oral free fatty acids, Oral triglycerides

ID: 55375855