TY - JOUR
T1 - Gastrointestinal hormones and appetite ratings after weight loss induced by diet or bariatric surgery
AU - Aukan, Marthe Isaksen
AU - Skårvold, Silje
AU - Brandsaeter, Ingrid Øfsti
AU - Rehfeld, Jens Frederik
AU - Holst, Jens Juul
AU - Nymo, Siren
AU - Coutinho, Silvia
AU - Martins, Catia
N1 - © 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2023/2
Y1 - 2023/2
N2 - OBJECTIVE: The aim of this study was to compare changes in gastrointestinal hormones and appetite ratings after a similar weight loss induced by a very low-energy diet alone or in combination with sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB).METHODS: Patients with severe obesity scheduled for SG (n = 15) and RYGB (n = 14) and 15 controls (very low-energy diet alone) were recruited. Body weight/composition, plasma concentrations of ß-hydroxybutyric acid, acylated ghrelin, total glucagon-like peptide-1, total peptide YY, cholecystokinin, and ratings of hunger, fullness, desire to eat, and prospective food consumption were measured pre- and postprandially, before and after 10 weeks of intervention.RESULTS: Changes in body weight/composition and level of ketosis were similar across groups. In SG and RYGB, basal and postprandial acylated ghrelin declined, and postprandial glucagon-like peptide-1 increased, both significantly more compared with controls. Postprandial peptide YY increased in all groups. Overall, postprandial hunger decreased, and postprandial fullness increased. But ratings of desire to eat and prospective food consumption were more favorable after both surgeries compared with controls.CONCLUSIONS: Weight loss with SG and RYGB leads to more favorable changes in gastrointestinal hormones compared with diet alone, although ratings of appetite were reduced across all groups.
AB - OBJECTIVE: The aim of this study was to compare changes in gastrointestinal hormones and appetite ratings after a similar weight loss induced by a very low-energy diet alone or in combination with sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB).METHODS: Patients with severe obesity scheduled for SG (n = 15) and RYGB (n = 14) and 15 controls (very low-energy diet alone) were recruited. Body weight/composition, plasma concentrations of ß-hydroxybutyric acid, acylated ghrelin, total glucagon-like peptide-1, total peptide YY, cholecystokinin, and ratings of hunger, fullness, desire to eat, and prospective food consumption were measured pre- and postprandially, before and after 10 weeks of intervention.RESULTS: Changes in body weight/composition and level of ketosis were similar across groups. In SG and RYGB, basal and postprandial acylated ghrelin declined, and postprandial glucagon-like peptide-1 increased, both significantly more compared with controls. Postprandial peptide YY increased in all groups. Overall, postprandial hunger decreased, and postprandial fullness increased. But ratings of desire to eat and prospective food consumption were more favorable after both surgeries compared with controls.CONCLUSIONS: Weight loss with SG and RYGB leads to more favorable changes in gastrointestinal hormones compared with diet alone, although ratings of appetite were reduced across all groups.
KW - Appetite
KW - Diet
KW - Gastrectomy
KW - Gastric Bypass
KW - Gastrointestinal Hormones
KW - Ghrelin
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Obesity, Morbid/surgery
KW - Peptide YY
KW - Weight Loss
UR - http://www.scopus.com/inward/record.url?scp=85144251264&partnerID=8YFLogxK
U2 - 10.1002/oby.23655
DO - 10.1002/oby.23655
M3 - Journal article
C2 - 36536482
VL - 31
SP - 399
EP - 411
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 2
ER -