Gastrin and cholecystokinin in pituitary neurons

J F Rehfeld; H F Hansen; L I Larsson; K Stengaard-Pedersen; N A Thorn

doi:10.1073/pnas.81.6.1902

Gastrin and cholecystokinin in pituitary neurons

J F Rehfeld, H F Hansen, L I Larsson, K Stengaard-Pedersen, N A Thorn

64 Citations (Scopus)

Abstract

Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varies from undetectable in pig and cat to 1 nmol/g in the cow. The constant occurrence of neurohypophyseal gastrin suggests a role different from that of the species-dependent CCK.

Original language	English
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	81
Issue number	6
Pages (from-to)	1902-5
Number of pages	4
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.81.6.1902
Publication status	Published - Mar 1984
Externally published	Yes

Keywords

Animals
Cats
Cattle
Cholecystokinin/metabolism
Gastrins/metabolism
Humans
Pituitary Gland/cytology
Rats
Swine

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10.1073/pnas.81.6.1902

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title = "Gastrin and cholecystokinin in pituitary neurons",

abstract = "Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varies from undetectable in pig and cat to 1 nmol/g in the cow. The constant occurrence of neurohypophyseal gastrin suggests a role different from that of the species-dependent CCK.",

keywords = "Animals, Cats, Cattle, Cholecystokinin/metabolism, Gastrins/metabolism, Humans, Pituitary Gland/cytology, Rats, Swine",

author = "Rehfeld, \{J F\} and Hansen, \{H F\} and Larsson, \{L I\} and K Stengaard-Pedersen and Thorn, \{N A\}",

year = "1984",

month = mar,

doi = "10.1073/pnas.81.6.1902",

language = "English",

volume = "81",

pages = "1902--5",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "6",

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TY - JOUR

T1 - Gastrin and cholecystokinin in pituitary neurons

AU - Rehfeld, J F

AU - Hansen, H F

AU - Larsson, L I

AU - Stengaard-Pedersen, K

AU - Thorn, N A

PY - 1984/3

Y1 - 1984/3

N2 - Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varies from undetectable in pig and cat to 1 nmol/g in the cow. The constant occurrence of neurohypophyseal gastrin suggests a role different from that of the species-dependent CCK.

AB - Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varies from undetectable in pig and cat to 1 nmol/g in the cow. The constant occurrence of neurohypophyseal gastrin suggests a role different from that of the species-dependent CCK.

KW - Animals

KW - Cats

KW - Cattle

KW - Cholecystokinin/metabolism

KW - Gastrins/metabolism

KW - Humans

KW - Pituitary Gland/cytology

KW - Rats

KW - Swine

UR - https://www.scopus.com/pages/publications/0021339745

U2 - 10.1073/pnas.81.6.1902

DO - 10.1073/pnas.81.6.1902

M3 - Journal article

C2 - 6584924

SN - 0027-8424

VL - 81

SP - 1902

EP - 1905

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 6

ER -

Gastrin and cholecystokinin in pituitary neurons

Abstract

Keywords

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