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Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study

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Harvard

Wölnerhanssen, BK, Drewe, J, Verbeure, W, le Roux, CW, Dellatorre-Teixeira, L, Rehfeld, JF, Holst, JJ, Hartmann, B, Tack, J, Peterli, R, Beglinger, C & Meyer-Gerspach, AC 2021, 'Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study', Diabetes, Obesity and Metabolism, vol. 23, no. 6, pp. 1311-1321. https://doi.org/10.1111/dom.14342

APA

Wölnerhanssen, B. K., Drewe, J., Verbeure, W., le Roux, C. W., Dellatorre-Teixeira, L., Rehfeld, J. F., Holst, J. J., Hartmann, B., Tack, J., Peterli, R., Beglinger, C., & Meyer-Gerspach, A. C. (2021). Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes, Obesity and Metabolism, 23(6), 1311-1321. https://doi.org/10.1111/dom.14342

CBE

Wölnerhanssen BK, Drewe J, Verbeure W, le Roux CW, Dellatorre-Teixeira L, Rehfeld JF, Holst JJ, Hartmann B, Tack J, Peterli R, Beglinger C, Meyer-Gerspach AC. 2021. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes, Obesity and Metabolism. 23(6):1311-1321. https://doi.org/10.1111/dom.14342

MLA

Vancouver

Author

Wölnerhanssen, Bettina K ; Drewe, Jürgen ; Verbeure, Wout ; le Roux, Carel W ; Dellatorre-Teixeira, Ludmilla ; Rehfeld, Jens F ; Holst, Jens J ; Hartmann, Bolette ; Tack, Jan ; Peterli, Ralph ; Beglinger, Christoph ; Meyer-Gerspach, Anne C. / Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans : A pilot dose-ranging study. In: Diabetes, Obesity and Metabolism. 2021 ; Vol. 23, No. 6. pp. 1311-1321.

Bibtex

@article{4d2a86d8220345d6b044f95cd1857d13,
title = "Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study",
abstract = "AIM: To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.MATERIALS AND METHODS: Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with 13 C-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (13 C-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.RESULTS: We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting.CONCLUSIONS: Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.",
keywords = "appetite-related sensations, blood lipids, erythritol, gastric emptying, gastrointestinal symptoms, gut hormones, natural sweeteners, uric acid",
author = "W{\"o}lnerhanssen, {Bettina K} and J{\"u}rgen Drewe and Wout Verbeure and {le Roux}, {Carel W} and Ludmilla Dellatorre-Teixeira and Rehfeld, {Jens F} and Holst, {Jens J} and Bolette Hartmann and Jan Tack and Ralph Peterli and Christoph Beglinger and Meyer-Gerspach, {Anne C}",
note = "{\textcopyright} 2021 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.",
year = "2021",
month = jun,
doi = "10.1111/dom.14342",
language = "English",
volume = "23",
pages = "1311--1321",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans

T2 - A pilot dose-ranging study

AU - Wölnerhanssen, Bettina K

AU - Drewe, Jürgen

AU - Verbeure, Wout

AU - le Roux, Carel W

AU - Dellatorre-Teixeira, Ludmilla

AU - Rehfeld, Jens F

AU - Holst, Jens J

AU - Hartmann, Bolette

AU - Tack, Jan

AU - Peterli, Ralph

AU - Beglinger, Christoph

AU - Meyer-Gerspach, Anne C

N1 - © 2021 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

PY - 2021/6

Y1 - 2021/6

N2 - AIM: To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.MATERIALS AND METHODS: Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with 13 C-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (13 C-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.RESULTS: We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting.CONCLUSIONS: Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.

AB - AIM: To determine whether a dose-dependent effect in the stimulation of gut hormone release (plasma cholecystokinin [CCK], active glucagon-like peptide-1 [aGLP-1] and peptide tyrosine tyrosine [PYY]) is found for the natural sweetener erythritol.MATERIALS AND METHODS: Twelve healthy, lean volunteers received solutions with 10, 25 or 50 g erythritol, or tap water enriched with 13 C-sodium acetate on four study days via a nasogastric tube in this randomized (active treatments), placebo-controlled, double-blind, cross-over trial. Blood samples and breath samples (13 C-sodium acetate method for measurement of gastric emptying [GE]) were taken at regular intervals, and sensations of appetite and gastrointestinal symptoms were rated.RESULTS: We found (a) a dose-dependent stimulation of CCK, aGLP-1 and PYY, and slowing of GE, (b) no effect on blood glucose, insulin, motilin, glucagon or glucose-dependent insulinotropic polypeptide, (c) no effect on blood lipids and uric acid, and (d) no abdominal pain, nausea or vomiting.CONCLUSIONS: Solutions with 10 and 50 g of erythritol stimulated gut hormone release. Emptying of erythritol-containing solutions from the stomach was slower compared with placebo. There was no effect on plasma glucose, insulin, glucagon, blood lipids or uric acid. All doses were well tolerated.

KW - appetite-related sensations

KW - blood lipids

KW - erythritol

KW - gastric emptying

KW - gastrointestinal symptoms

KW - gut hormones

KW - natural sweeteners

KW - uric acid

UR - http://www.scopus.com/inward/record.url?scp=85101743725&partnerID=8YFLogxK

U2 - 10.1111/dom.14342

DO - 10.1111/dom.14342

M3 - Journal article

C2 - 33565706

VL - 23

SP - 1311

EP - 1321

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 6

ER -

ID: 65558818