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Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles

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Jarak, I, Pereira, SS, Carvalho, RA, Oliveira, PF, Alves, MG, Guimarães, M, Wewer Albrechtsen, NJ, Holst, JJ, Nora, M & Monteiro, MP 2020, 'Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles' Obesity Surgery, vol. 30, no. 3, pp. 1068-1078. https://doi.org/10.1007/s11695-019-04294-5

APA

Jarak, I., Pereira, S. S., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimarães, M., ... Monteiro, M. P. (2020). Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles. Obesity Surgery, 30(3), 1068-1078. https://doi.org/10.1007/s11695-019-04294-5

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Author

Jarak, Ivana ; Pereira, Sofia S ; Carvalho, Rui A ; Oliveira, Pedro F ; Alves, Marco G ; Guimarães, Marta ; Wewer Albrechtsen, Nicolai J ; Holst, Jens J ; Nora, Mário ; Monteiro, Mariana P. / Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles. In: Obesity Surgery. 2020 ; Vol. 30, No. 3. pp. 1068-1078.

Bibtex

@article{15f59043b06d42faacc7a91578383e57,
title = "Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles",
abstract = "BACKGROUND/AIM: Roux-en-Y gastric bypass (RYGB) with a long biliopancreatic limb (BPL) was demonstrated to further improve type 2 diabetes (T2D) outcomes. Whether benefits occur at the cost of a negative impact on nutrient absorption is a matter of debate. Our aim was to evaluate the impact of RYGB BPL length on short-term nutrient absorption.METHODS: Subjects (N = 20) submitted to RYGB with a 2 m BPL (n = 11) or standard BPL (60-100 cm) (n = 9) 4.2 ± 0.4 years earlier underwent a mixed meal tolerance test. Plasma metabolites were analyzed at baseline and after meal by nuclear magnetic resonance (NMR) spectroscopy. Spectra were subject to multivariate analysis (MVA). Partial least square discriminant analysis (PLS-DA) was used to identify metabolites responsible for group discrimination.RESULTS: Principal component analysis and PLS-DA showed a clear separation between plasma metabolites before and 30 min after meal intake in both groups. The metabolites responsible for differences between time points were glucose and branched-chain amino acids. A complete overlap in metabolite species and concentrations was observed at 0 and 30 min time points for both groups, while acetate levels 120 min after the meal intake were significantly higher in subjects submitted to RYGB with a 2-m-long BPL as compared to the group submitted to the standard RYGB procedure.CONCLUSIONS: Post-prandial plasma metabolomics profiles suggest that a 2-m-long BLP RYGB does not have a negative impact on acute metabolite absorption. RYGB BPL length seems to influence post-prandial acetate levels, which could contribute to the additional positive metabolic outcomes.",
author = "Ivana Jarak and Pereira, {Sofia S} and Carvalho, {Rui A} and Oliveira, {Pedro F} and Alves, {Marco G} and Marta Guimar{\~a}es and {Wewer Albrechtsen}, {Nicolai J} and Holst, {Jens J} and M{\'a}rio Nora and Monteiro, {Mariana P}",
year = "2020",
month = "3",
doi = "10.1007/s11695-019-04294-5",
language = "English",
volume = "30",
pages = "1068--1078",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer New York LLC",
number = "3",

}

RIS

TY - JOUR

T1 - Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles

AU - Jarak, Ivana

AU - Pereira, Sofia S

AU - Carvalho, Rui A

AU - Oliveira, Pedro F

AU - Alves, Marco G

AU - Guimarães, Marta

AU - Wewer Albrechtsen, Nicolai J

AU - Holst, Jens J

AU - Nora, Mário

AU - Monteiro, Mariana P

PY - 2020/3

Y1 - 2020/3

N2 - BACKGROUND/AIM: Roux-en-Y gastric bypass (RYGB) with a long biliopancreatic limb (BPL) was demonstrated to further improve type 2 diabetes (T2D) outcomes. Whether benefits occur at the cost of a negative impact on nutrient absorption is a matter of debate. Our aim was to evaluate the impact of RYGB BPL length on short-term nutrient absorption.METHODS: Subjects (N = 20) submitted to RYGB with a 2 m BPL (n = 11) or standard BPL (60-100 cm) (n = 9) 4.2 ± 0.4 years earlier underwent a mixed meal tolerance test. Plasma metabolites were analyzed at baseline and after meal by nuclear magnetic resonance (NMR) spectroscopy. Spectra were subject to multivariate analysis (MVA). Partial least square discriminant analysis (PLS-DA) was used to identify metabolites responsible for group discrimination.RESULTS: Principal component analysis and PLS-DA showed a clear separation between plasma metabolites before and 30 min after meal intake in both groups. The metabolites responsible for differences between time points were glucose and branched-chain amino acids. A complete overlap in metabolite species and concentrations was observed at 0 and 30 min time points for both groups, while acetate levels 120 min after the meal intake were significantly higher in subjects submitted to RYGB with a 2-m-long BPL as compared to the group submitted to the standard RYGB procedure.CONCLUSIONS: Post-prandial plasma metabolomics profiles suggest that a 2-m-long BLP RYGB does not have a negative impact on acute metabolite absorption. RYGB BPL length seems to influence post-prandial acetate levels, which could contribute to the additional positive metabolic outcomes.

AB - BACKGROUND/AIM: Roux-en-Y gastric bypass (RYGB) with a long biliopancreatic limb (BPL) was demonstrated to further improve type 2 diabetes (T2D) outcomes. Whether benefits occur at the cost of a negative impact on nutrient absorption is a matter of debate. Our aim was to evaluate the impact of RYGB BPL length on short-term nutrient absorption.METHODS: Subjects (N = 20) submitted to RYGB with a 2 m BPL (n = 11) or standard BPL (60-100 cm) (n = 9) 4.2 ± 0.4 years earlier underwent a mixed meal tolerance test. Plasma metabolites were analyzed at baseline and after meal by nuclear magnetic resonance (NMR) spectroscopy. Spectra were subject to multivariate analysis (MVA). Partial least square discriminant analysis (PLS-DA) was used to identify metabolites responsible for group discrimination.RESULTS: Principal component analysis and PLS-DA showed a clear separation between plasma metabolites before and 30 min after meal intake in both groups. The metabolites responsible for differences between time points were glucose and branched-chain amino acids. A complete overlap in metabolite species and concentrations was observed at 0 and 30 min time points for both groups, while acetate levels 120 min after the meal intake were significantly higher in subjects submitted to RYGB with a 2-m-long BPL as compared to the group submitted to the standard RYGB procedure.CONCLUSIONS: Post-prandial plasma metabolomics profiles suggest that a 2-m-long BLP RYGB does not have a negative impact on acute metabolite absorption. RYGB BPL length seems to influence post-prandial acetate levels, which could contribute to the additional positive metabolic outcomes.

U2 - 10.1007/s11695-019-04294-5

DO - 10.1007/s11695-019-04294-5

M3 - Journal article

VL - 30

SP - 1068

EP - 1078

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

IS - 3

ER -

ID: 59932590