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Gastric bypass with different biliopancreatic limb lengths results in similar post-absorptive metabolomics profiles

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  1. Different malabsorptive obesity surgery interventions result in distinct postprandial amino acid metabolomic signatures

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  3. Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia

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  4. Bone health in patients with type 2 diabetes treated by Roux-En-Y gastric bypass and the role of diabetes remission

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Different malabsorptive obesity surgery interventions result in distinct postprandial amino acid metabolomic signatures

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

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  3. Interleukin-6 may not affect bone resorption marker CTX or bone formation marker P1NP in humans

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  4. Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Ivana Jarak
  • Sofia S Pereira
  • Rui A Carvalho
  • Pedro F Oliveira
  • Marco G Alves
  • Marta Guimarães
  • Nicolai J Wewer Albrechtsen
  • Jens J Holst
  • Mário Nora
  • Mariana P Monteiro
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BACKGROUND/AIM: Roux-en-Y gastric bypass (RYGB) with a long biliopancreatic limb (BPL) was demonstrated to further improve type 2 diabetes (T2D) outcomes. Whether benefits occur at the cost of a negative impact on nutrient absorption is a matter of debate. Our aim was to evaluate the impact of RYGB BPL length on short-term nutrient absorption.

METHODS: Subjects (N = 20) submitted to RYGB with a 2 m BPL (n = 11) or standard BPL (60-100 cm) (n = 9) 4.2 ± 0.4 years earlier underwent a mixed meal tolerance test. Plasma metabolites were analyzed at baseline and after meal by nuclear magnetic resonance (NMR) spectroscopy. Spectra were subject to multivariate analysis (MVA). Partial least square discriminant analysis (PLS-DA) was used to identify metabolites responsible for group discrimination.

RESULTS: Principal component analysis and PLS-DA showed a clear separation between plasma metabolites before and 30 min after meal intake in both groups. The metabolites responsible for differences between time points were glucose and branched-chain amino acids. A complete overlap in metabolite species and concentrations was observed at 0 and 30 min time points for both groups, while acetate levels 120 min after the meal intake were significantly higher in subjects submitted to RYGB with a 2-m-long BPL as compared to the group submitted to the standard RYGB procedure.

CONCLUSIONS: Post-prandial plasma metabolomics profiles suggest that a 2-m-long BLP RYGB does not have a negative impact on acute metabolite absorption. RYGB BPL length seems to influence post-prandial acetate levels, which could contribute to the additional positive metabolic outcomes.

Original languageEnglish
JournalObesity Surgery
Volume30
Issue number3
Pages (from-to)1068-1078
Number of pages11
ISSN0960-8923
DOIs
Publication statusPublished - Mar 2020

ID: 59932590