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Gamma-glutamyltransferase, aspartate aminotransferase and alkaline phosphatase as markers of alcohol consumption in out-patient alcoholics

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  • C Gluud
  • I Andersen
  • O Dietrichson
  • B Gluud
  • A Jacobsen
  • E Juhl
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Serum activity of gamma-glutamyltransferase, aspartate aminotransferase and alkaline phosphatase were determined in 316 patients attending an out-patients clinic for treatment of alcoholism. The activity of gamma-glutamyltransferase was raised in 34% and that of aspartate aminotransferase and alkaline phosphatase in 18% and 7%. Neither the activity of gamma-glutamyltransferase, aspartate aminotransferase nor alkaline phosphatase showed any significant (P greater than 0.05) correlation with the history of alcohol consumption. The activities of gamma-glutamyltransferase and aspartate aminotransferase were raised significantly more often in patients with recent alcohol consumption than in patients who had abstained for more than 9 days. The concentration of alkaline phosphatase was not significantly (P greater than 0.05) different in these groups. The predictive value of raised and normal activities of gamma-glutamyltransferase, in deciding whether a patient had had recent alcohol consumption or not, was not superior to the predictive value of raised and normal activities of aspartate aminotransferase.
Original languageEnglish
JournalEuropean Journal of Clinical Investigation
Volume11
Issue number3
Pages (from-to)171-6
Number of pages6
ISSN0014-2972
Publication statusPublished - Jun 1981

    Research areas

  • Adult, Aged, Alcohol Drinking, Alcoholism, Alkaline Phosphatase, Ambulatory Care, Aspartate Aminotransferases, Clinical Enzyme Tests, Disulfiram, Female, Follow-Up Studies, Humans, Male, Middle Aged, gamma-Glutamyltransferase

ID: 38929602