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GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development

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The ability of the GABA receptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) to promote formation of low affinity GABA receptors on cerebellar granule cells was tested using primary cultures of these neurons. Granule cells were exposed to THIP (150 microM) for 6 hr after, respectively, 4, 7, 10 and 14 days in culture. It was found that THIP treatment of 4- and 7-day-old cultures led to formation of low affinity GABA receptors, whereas such receptors could not be detected after THIP treatment in the older cultures (10 and 14 days) in spite of the fact that these cultured granule cells expressed a high density of high affinity GABA receptors. It is concluded that the ability of THIP to promote formation of low affinity GABA receptors on cerebellar granule cells is restricted to an early developmental period.
Original languageEnglish
JournalInternational Journal of Developmental Neuroscience
Volume6
Issue number2
Pages (from-to)125-8
Number of pages4
ISSN0736-5748
Publication statusPublished - 1 Jan 1988

ID: 32359169