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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Functional sympatholysis during exercise in patients with type 2 diabetes with intact response to acetylcholine

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DOI

  1. Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy

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  2. Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes

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  3. Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study

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  4. Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

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  5. Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People

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Sympathetic vasoconstriction is blunted in contracting human skeletal muscles (functional sympatholysis). In young subjects, infusion of adenosine and ATP increases blood flow, and the latter compound also attenuates α-adrenergic vasoconstriction. In patients with type 2 diabetes and age-matched healthy subjects, we tested 1) the sympatholytic capacity during one-legged exercise, 2) the vasodilatory capacity of adenosine and ATP, and 3) the ability to blunt α-adrenergic vasoconstriction during ATP infusion.
Original languageEnglish
JournalDiabetes Care
Volume34
Issue number5
Pages (from-to)1186-91
Number of pages6
ISSN0149-5992
DOIs
Publication statusPublished - 2011

    Research areas

  • Acetylcholine, Adenosine, Adenosine Triphosphate, Age Factors, Diabetes Mellitus, Type 2, Exercise, Female, Humans, Hyperemia, Male, Middle Aged, Muscle, Skeletal, Regional Blood Flow, Vasoconstriction

ID: 33280197