Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Changes in metabolism but not myocellular signaling by training with CHO-restriction in endurance athletes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Infants with congenital heart defects have reduced brain volumes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exploring patient experiences in the student outpatient clinic - A contribution to learning

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cardiac Arrhythmias and Impaired Heart Rate Variability in Older Patients With Ventricular Septal Defects

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Lymphatic Function in the Arms of Breast Cancer Patients-A Prospective Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Sheyanth Mohanakumar
  • Benjamin Kelly
  • Aida Luiza Ribeiro Turquetto
  • Mathias Alstrup
  • Luciana Patrick Amato
  • Milena Schiezari Ru Barnabe
  • João Bruno Dias Silveira
  • Fernando Amaral
  • Paulo Henrique Manso
  • Marcelo Biscegli Jatene
  • Vibeke Elisabeth Hjortdal
View graph of relations

BACKGROUND: Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near-infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to healthy controls. It is proposed that the elevated lymphatic pumping seen in the Fontan patients is necessary to maintain habitual interstitial fluid balance. Hyperthermia has previously been used as a tool for lymphatic stress test. By increasing fluid filtration in the capillary bed, the lymphatic workload and contraction frequency are increased accordingly. Using near-infrared fluorescence imaging, the lymphatic functional reserve capacity in Fontan patients were explored with a lymphatic stress test.

METHODS: Fontan patients (n = 33) were compared to a group of 15 healthy individuals of equal age, weight, and gender. The function of the superficial lymphatic vessels in the lower leg during rest and after inducing hyperthermia was investigated, using near-infrared fluorescence imaging.

RESULTS: Baseline values in the Fontan patients showed a 57% higher contraction frequency compared to the healthy controls (0.4 ± 0.3 min-1 vs. 0.3 ± 0.2 min-1 , p = 0.0445). After inducing stress on the lymphatic vessels with hyperthermia the ability to increase contraction frequency was decreased in the Fontan patients compared to the controls (0.6 ± 0.5 min-1 vs. 1.2 ± 0.8 min-1 , p = 0.0102).

CONCLUSIONS: Fontan patients had a higher lymphatic contraction frequency during normal circumstances. In the Fontan patients, the hyperthermia response is dampened indicating that the functional lymphatic reserve capacity is depressed. This diminished reserve capacity could be part of the explanation as to why some Fontan patients develop late-onset lymphatic complications.

Original languageEnglish
Article numbere14862
JournalPhysiological Reports
Volume9
Issue number11
Pages (from-to)e14862
ISSN2051-817X
DOIs
Publication statusPublished - Jun 2021

Bibliographical note

© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

ID: 68336470