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Functional impairment, symptom severity, and overall quality of life in patients with advanced lung or colorectal cancer in six European countries: baseline findings from the ACTION study

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Verkissen, Mariëtte N ; De Vleminck, Aline ; Groenvold, Mogens ; Jabbarian, Lea J ; Bulli, Francesco ; Cools, Wilfried ; van Delden, Johannes J M ; Lunder, Urška ; Miccinesi, Guido ; Payne, Sheila A ; Pollock, Kristian ; Rietjens, Judith A C ; Deliens, Luc. / Functional impairment, symptom severity, and overall quality of life in patients with advanced lung or colorectal cancer in six European countries : baseline findings from the ACTION study. In: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2021 ; Vol. 29, No. 10. pp. 5797-5810.

Bibtex

@article{3a92a73e6c164922903fc4a153292b23,
title = "Functional impairment, symptom severity, and overall quality of life in patients with advanced lung or colorectal cancer in six European countries: baseline findings from the ACTION study",
abstract = "BACKGROUND: People with advanced cancer often suffer from various symptoms, which can arise from the cancer itself and its treatment, the illness experience, and/or co-morbid conditions. Important patient-reported outcomes such as functional status, symptom severity, and quality of life (QoL) might differ between countries, as countries vary with regard to contextual factors such as their healthcare system.PURPOSE: To assess self-reported emotional functioning, physical functioning, symptoms, and overall QoL in patients with advanced lung or colorectal cancer from six European countries, particularly in relation to their country of residence.METHODS: We used baseline patient data from the ACTION trial, including socio-demographic and clinical data as well as patient-reported data regarding functioning, symptoms, and overall QoL (EORTC QLQ-C15-PAL).RESULTS: Data from 1117 patients (55% lung cancer stage III/IV, 45% colorectal cancer stage IV) were used. The highest (worst) average symptom score was found for fatigue. We found similarities but also important differences in the outcomes across countries. The best scores (the highest for emotional functioning and QoL, the lowest for symptoms) were reported by Dutch and Danish patients. Belgian patients reported relatively low emotional functioning.CONCLUSION: The optimization of functioning, symptom relief, and overall QoL should be important objectives of healthcare professionals who take care of patients with advanced cancer. There are similarities, but also substantial differences across countries in functional status, symptoms, and overall QoL. Policymakers should take these differences into account and invest in offering health care catered to the needs of their population.",
keywords = "Advanced cancer, Colorectal cancer, Functional status, Lung cancer, Palliative care, Quality of life, Symptoms",
author = "Verkissen, {Mari{\"e}tte N} and {De Vleminck}, Aline and Mogens Groenvold and Jabbarian, {Lea J} and Francesco Bulli and Wilfried Cools and {van Delden}, {Johannes J M} and Ur{\v s}ka Lunder and Guido Miccinesi and Payne, {Sheila A} and Kristian Pollock and Rietjens, {Judith A C} and Luc Deliens",
note = "{\textcopyright} 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2021",
month = oct,
doi = "10.1007/s00520-021-06150-8",
language = "English",
volume = "29",
pages = "5797--5810",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Functional impairment, symptom severity, and overall quality of life in patients with advanced lung or colorectal cancer in six European countries

T2 - baseline findings from the ACTION study

AU - Verkissen, Mariëtte N

AU - De Vleminck, Aline

AU - Groenvold, Mogens

AU - Jabbarian, Lea J

AU - Bulli, Francesco

AU - Cools, Wilfried

AU - van Delden, Johannes J M

AU - Lunder, Urška

AU - Miccinesi, Guido

AU - Payne, Sheila A

AU - Pollock, Kristian

AU - Rietjens, Judith A C

AU - Deliens, Luc

N1 - © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2021/10

Y1 - 2021/10

N2 - BACKGROUND: People with advanced cancer often suffer from various symptoms, which can arise from the cancer itself and its treatment, the illness experience, and/or co-morbid conditions. Important patient-reported outcomes such as functional status, symptom severity, and quality of life (QoL) might differ between countries, as countries vary with regard to contextual factors such as their healthcare system.PURPOSE: To assess self-reported emotional functioning, physical functioning, symptoms, and overall QoL in patients with advanced lung or colorectal cancer from six European countries, particularly in relation to their country of residence.METHODS: We used baseline patient data from the ACTION trial, including socio-demographic and clinical data as well as patient-reported data regarding functioning, symptoms, and overall QoL (EORTC QLQ-C15-PAL).RESULTS: Data from 1117 patients (55% lung cancer stage III/IV, 45% colorectal cancer stage IV) were used. The highest (worst) average symptom score was found for fatigue. We found similarities but also important differences in the outcomes across countries. The best scores (the highest for emotional functioning and QoL, the lowest for symptoms) were reported by Dutch and Danish patients. Belgian patients reported relatively low emotional functioning.CONCLUSION: The optimization of functioning, symptom relief, and overall QoL should be important objectives of healthcare professionals who take care of patients with advanced cancer. There are similarities, but also substantial differences across countries in functional status, symptoms, and overall QoL. Policymakers should take these differences into account and invest in offering health care catered to the needs of their population.

AB - BACKGROUND: People with advanced cancer often suffer from various symptoms, which can arise from the cancer itself and its treatment, the illness experience, and/or co-morbid conditions. Important patient-reported outcomes such as functional status, symptom severity, and quality of life (QoL) might differ between countries, as countries vary with regard to contextual factors such as their healthcare system.PURPOSE: To assess self-reported emotional functioning, physical functioning, symptoms, and overall QoL in patients with advanced lung or colorectal cancer from six European countries, particularly in relation to their country of residence.METHODS: We used baseline patient data from the ACTION trial, including socio-demographic and clinical data as well as patient-reported data regarding functioning, symptoms, and overall QoL (EORTC QLQ-C15-PAL).RESULTS: Data from 1117 patients (55% lung cancer stage III/IV, 45% colorectal cancer stage IV) were used. The highest (worst) average symptom score was found for fatigue. We found similarities but also important differences in the outcomes across countries. The best scores (the highest for emotional functioning and QoL, the lowest for symptoms) were reported by Dutch and Danish patients. Belgian patients reported relatively low emotional functioning.CONCLUSION: The optimization of functioning, symptom relief, and overall QoL should be important objectives of healthcare professionals who take care of patients with advanced cancer. There are similarities, but also substantial differences across countries in functional status, symptoms, and overall QoL. Policymakers should take these differences into account and invest in offering health care catered to the needs of their population.

KW - Advanced cancer

KW - Colorectal cancer

KW - Functional status

KW - Lung cancer

KW - Palliative care

KW - Quality of life

KW - Symptoms

UR - http://www.scopus.com/inward/record.url?scp=85103207937&partnerID=8YFLogxK

U2 - 10.1007/s00520-021-06150-8

DO - 10.1007/s00520-021-06150-8

M3 - Journal article

C2 - 33742242

VL - 29

SP - 5797

EP - 5810

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 10

ER -

ID: 67449800