Fuldgenom-DNA-sekventering til overvågning af bakterielle infektionssygdomme

Michael Kemp; Xiaohui Chen Nielsen; Mette Damkjær Batels; Henrik Hasman; Eva Møller Nielsen

Fuldgenom-DNA-sekventering til overvågning af bakterielle infektionssygdomme

Translated title of the contribution: Whole genome sequencing for surveillance of bacterial infectious illnesses

Michael Kemp, Xiaohui Chen Nielsen, Mette Damkjær Batels, Henrik Hasman, Eva Møller Nielsen

Department of Clinical Microbiology

Abstract

This review summarises the current knowledge of whole genome sequencing (WGS) which has become the standard method for genetic characterisation of bacteria in surveillance and outbreak investigation. Although the method offers many advantages, its use in outbreak investigations is hampered by the relatively slow turn-around time. Using new approaches to perform WGS, typing and gene detection can now be completed within one day. This break-through allows clinical consequences to be taken almost immediately after detection of relevant bacteria and may have a huge impact on the future prevention of transmission of infectious diseases.

Translated title of the contribution	Whole genome sequencing for surveillance of bacterial infectious illnesses
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	185
Issue number	22
ISSN	0041-5782
Publication status	Published - 29 May 2023

Cite this

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title = "Fuldgenom-DNA-sekventering til overv{\aa}gning af bakterielle infektionssygdomme",

abstract = "This review summarises the current knowledge of whole genome sequencing (WGS) which has become the standard method for genetic characterisation of bacteria in surveillance and outbreak investigation. Although the method offers many advantages, its use in outbreak investigations is hampered by the relatively slow turn-around time. Using new approaches to perform WGS, typing and gene detection can now be completed within one day. This break-through allows clinical consequences to be taken almost immediately after detection of relevant bacteria and may have a huge impact on the future prevention of transmission of infectious diseases.",

keywords = "Humans, Whole Genome Sequencing/methods, Bacterial Infections, Disease Outbreaks/prevention \& control",

author = "Michael Kemp and Nielsen, \{Xiaohui Chen\} and Batels, \{Mette Damkj{\ae}r\} and Henrik Hasman and Nielsen, \{Eva M{\o}ller\}",

year = "2023",

month = may,

day = "29",

language = "Dansk",

volume = "185",

journal = "Ugeskrift for Laeger",

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TY - JOUR

T1 - Fuldgenom-DNA-sekventering til overvågning af bakterielle infektionssygdomme

AU - Kemp, Michael

AU - Nielsen, Xiaohui Chen

AU - Batels, Mette Damkjær

AU - Hasman, Henrik

AU - Nielsen, Eva Møller

PY - 2023/5/29

Y1 - 2023/5/29

N2 - This review summarises the current knowledge of whole genome sequencing (WGS) which has become the standard method for genetic characterisation of bacteria in surveillance and outbreak investigation. Although the method offers many advantages, its use in outbreak investigations is hampered by the relatively slow turn-around time. Using new approaches to perform WGS, typing and gene detection can now be completed within one day. This break-through allows clinical consequences to be taken almost immediately after detection of relevant bacteria and may have a huge impact on the future prevention of transmission of infectious diseases.

AB - This review summarises the current knowledge of whole genome sequencing (WGS) which has become the standard method for genetic characterisation of bacteria in surveillance and outbreak investigation. Although the method offers many advantages, its use in outbreak investigations is hampered by the relatively slow turn-around time. Using new approaches to perform WGS, typing and gene detection can now be completed within one day. This break-through allows clinical consequences to be taken almost immediately after detection of relevant bacteria and may have a huge impact on the future prevention of transmission of infectious diseases.

KW - Humans

KW - Whole Genome Sequencing/methods

KW - Bacterial Infections

KW - Disease Outbreaks/prevention & control

UR - https://ugeskriftet.dk/videnskab/fuldgenom-dna-sekventering-til-overvagning-af-bakterielle-infektionssygdomme

UR - https://www.scopus.com/pages/publications/85160967325

M3 - Review

C2 - 37264858

SN - 0041-5782

VL - 185

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 22

ER -

Fuldgenom-DNA-sekventering til overvågning af bakterielle infektionssygdomme

Abstract

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