Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

From mechanical loading to collagen synthesis, structural changes and function in human tendon

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effect of blood-flow restricted vs. heavy-load strength training on muscle strength: Systematic review and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prevalence and severity of groin problems in Spanish football: A prospective study beyond the time-loss approach

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cardiovascular and metabolic health effects of team handball training in overweight women: Impact of prior experience

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Physical activity during pregnancy and intelligence in sons; A cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Influence of between-limb asymmetry in muscle mass, strength, and power on functional capacity in healthy older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Simulation of advanced cataract surgery - validation of a newly developed test

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Maintenance of muscle strength following a one-year resistance training program in older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The adaptive response of connective tissue to loading requires increased synthesis and turnover of matrix proteins, with special emphasis on collagen. Collagen formation and degradation in the tendon increases with both acute and chronic loading, and data suggest that a gender difference exists, in that females respond less than males with regard to an increase in collagen formation after exercise. It is suggested that estrogen may contribute toward a diminished collagen synthesis response in females. Conversely, the stimulation of collagen synthesis by other growth factors can be shown in both animal and human models where insulin-like growth factor 1 (IGF-I) and transforming growth factor-beta-1 (TGF-beta-1) expression increases to accompany or precede an increase in procollagen expression and collagen synthesis. In humans, it can be demonstrated that an increase in the interstitial concentration of TGF-beta, PGE2, IGF-I plus its binding proteins and interleukin-6 takes place after exercise. The increase in IGF-I expression in tendon includes the isoform that has so far been thought only to exist in skeletal muscle (mechano growth factor). The increase in IGF-I and procollagen expression showed a similar response whether the tendon was stimulated by concentric, isometric or eccentric muscle contraction, suggesting that strain rather that stress/torque determines the collagen-synthesis stimulating response seen with exercise. The adaptation time to chronic loading is longer in tendon tissue compared with contractile elements of skeletal muscle or the heart, and only with very prolonged loading are significant changes in gross dimensions of the tendon observed, suggesting that habitual loading is associated with a robust change in the size and mechanical properties of human tendons. An intimate interplay between mechanical signalling and biochemical changes in the matrix is needed in tendon, such that chemical changes can be converted into adaptations in the morphology, structure and material properties.

Original languageEnglish
JournalScandinavian journal of medicine & science in sports
Volume19
Issue number4
Pages (from-to)500-10
Number of pages11
ISSN0905-7188
DOIs
Publication statusPublished - Aug 2009

    Research areas

  • Actins, Animals, Biomechanical Phenomena, Collagen, Dinoprostone, Exercise, Female, Humans, Insulin-Like Growth Factor I, Interleukin-6, Male, Sex Factors, Somatomedins, Tendon Injuries, Tendons, Transforming Growth Factor beta, Weight-Bearing

ID: 45104245