Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas

Nicolai Aagaard Schultz; Anne Roslind; Ib J Christensen; Thomas Horn; Estrid Høgdall; Lisbeth Nørum Pedersen; Mogens Kruhøffer; Flemming Burcharth; Morten Wøjdemann; Julia S Johansen

doi:10.1097/MPA.0b013e31823cd9df

Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas

Nicolai Aagaard Schultz, Anne Roslind, Ib J Christensen, Thomas Horn, Estrid Høgdall, Lisbeth Nørum Pedersen, Mogens Kruhøffer, Flemming Burcharth, Morten Wøjdemann, Julia S Johansen

59 Citations (Scopus)

Abstract

The frequencies and prognostic role of KRAS and BRAF mutations in patients operated on for pancreatic ductal adenocarcinomas (PDACs) and ampullary adenocarcinomas (A-ACs) are scantily studied.

Original language	English
Journal	Pancreas
Volume	41
Issue number	5
Pages (from-to)	759-66
Number of pages	8
ISSN	0885-3177
DOIs	https://doi.org/10.1097/MPA.0b013e31823cd9df
Publication status	Published - 2012

Keywords

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Ampulla of Vater
Carcinoma, Pancreatic Ductal
Female
Gene Frequency
Genotype
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Mutation
Neoplasm Staging
Pancreatic Neoplasms
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins B-raf
Smoking
ras Proteins

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10.1097/MPA.0b013e31823cd9df

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title = "Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas",

abstract = "The frequencies and prognostic role of KRAS and BRAF mutations in patients operated on for pancreatic ductal adenocarcinomas (PDACs) and ampullary adenocarcinomas (A-ACs) are scantily studied.",

keywords = "Adenocarcinoma, Adult, Aged, Aged, 80 and over, Ampulla of Vater, Carcinoma, Pancreatic Ductal, Female, Gene Frequency, Genotype, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Mutation, Neoplasm Staging, Pancreatic Neoplasms, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Smoking, ras Proteins",

author = "Schultz, {Nicolai Aagaard} and Anne Roslind and Christensen, {Ib J} and Thomas Horn and Estrid H{\o}gdall and Pedersen, {Lisbeth N{\o}rum} and Mogens Kruh{\o}ffer and Flemming Burcharth and Morten W{\o}jdemann and Johansen, {Julia S}",

year = "2012",

doi = "10.1097/MPA.0b013e31823cd9df",

language = "English",

volume = "41",

pages = "759--66",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams & Wilkins",

number = "5",

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TY - JOUR

T1 - Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas

AU - Schultz, Nicolai Aagaard

AU - Roslind, Anne

AU - Christensen, Ib J

AU - Horn, Thomas

AU - Høgdall, Estrid

AU - Pedersen, Lisbeth Nørum

AU - Kruhøffer, Mogens

AU - Burcharth, Flemming

AU - Wøjdemann, Morten

AU - Johansen, Julia S

PY - 2012

Y1 - 2012

N2 - The frequencies and prognostic role of KRAS and BRAF mutations in patients operated on for pancreatic ductal adenocarcinomas (PDACs) and ampullary adenocarcinomas (A-ACs) are scantily studied.

AB - The frequencies and prognostic role of KRAS and BRAF mutations in patients operated on for pancreatic ductal adenocarcinomas (PDACs) and ampullary adenocarcinomas (A-ACs) are scantily studied.

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Ampulla of Vater

KW - Carcinoma, Pancreatic Ductal

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Mutation

KW - Neoplasm Staging

KW - Pancreatic Neoplasms

KW - Prognosis

KW - Proto-Oncogene Proteins

KW - Proto-Oncogene Proteins B-raf

KW - Smoking

KW - ras Proteins

U2 - 10.1097/MPA.0b013e31823cd9df

DO - 10.1097/MPA.0b013e31823cd9df

M3 - Journal article

C2 - 22699145

SN - 0885-3177

VL - 41

SP - 759

EP - 766

JO - Pancreas

JF - Pancreas

IS - 5

ER -

Frequencies and prognostic role of KRAS and BRAF mutations in patients with localized pancreatic and ampullary adenocarcinomas

Abstract

Keywords

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