Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing

Niels Høiby; Helle Krogh Johansen; Oana Ciofu; Peter Ø Jensen; Thomas Bjarnsholt; Michael Christian Givskov

Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing

Translated title of the contribution: [Foreign body infections--biofilms and quorum sensing]

Niels Høiby, Helle Krogh Johansen, Oana Ciofu, Peter Ø Jensen, Thomas Bjarnsholt, Michael Christian Givskov

Department of Clinical Microbiology

5 Citations (Scopus)

Abstract

Biofilms are structured consortia of bacteria embedded in self-produced polymer matrix. Biofilms are resistant to antibiotics, disinfectives and phagocytosis. The persistence of foreign body infections is due to biofilms. Chronic P. aeruginosa lung infection in cystic fibrosis patients is a biofilm. Bacteria in biofilms communicate by means of quorum sensing which activates genes for virulence factors. Biofilms can be prevented by antibiotic prophylaxis or early therapy or by quorum sensing inhibitors which make them susceptible to antibiotics and phagocytosis.

Translated title of the contribution	[Foreign body infections--biofilms and quorum sensing]
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	169
Issue number	48
Pages (from-to)	4163-6
Number of pages	4
ISSN	0041-5782
Publication status	Published - 26 Nov 2007

Cite this

@article{31f69f2efea942f0b1382c33d1e34974,

title = "Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing",

abstract = "Biofilms are structured consortia of bacteria embedded in self-produced polymer matrix. Biofilms are resistant to antibiotics, disinfectives and phagocytosis. The persistence of foreign body infections is due to biofilms. Chronic P. aeruginosa lung infection in cystic fibrosis patients is a biofilm. Bacteria in biofilms communicate by means of quorum sensing which activates genes for virulence factors. Biofilms can be prevented by antibiotic prophylaxis or early therapy or by quorum sensing inhibitors which make them susceptible to antibiotics and phagocytosis.",

keywords = "Anti-Bacterial Agents, Antibiotic Prophylaxis, Biofilms, Drug Resistance, Bacterial, Foreign-Body Reaction, Humans, Infection Control, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing",

author = "Niels H{\o}iby and Johansen, \{Helle Krogh\} and Oana Ciofu and Jensen, \{Peter {\O}\} and Thomas Bjarnsholt and Givskov, \{Michael Christian\}",

year = "2007",

month = nov,

day = "26",

language = "Dansk",

volume = "169",

pages = "4163--6",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske L{\ae}geforening",

number = "48",

}

TY - JOUR

T1 - Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing

AU - Høiby, Niels

AU - Johansen, Helle Krogh

AU - Ciofu, Oana

AU - Jensen, Peter Ø

AU - Bjarnsholt, Thomas

AU - Givskov, Michael Christian

PY - 2007/11/26

Y1 - 2007/11/26

N2 - Biofilms are structured consortia of bacteria embedded in self-produced polymer matrix. Biofilms are resistant to antibiotics, disinfectives and phagocytosis. The persistence of foreign body infections is due to biofilms. Chronic P. aeruginosa lung infection in cystic fibrosis patients is a biofilm. Bacteria in biofilms communicate by means of quorum sensing which activates genes for virulence factors. Biofilms can be prevented by antibiotic prophylaxis or early therapy or by quorum sensing inhibitors which make them susceptible to antibiotics and phagocytosis.

AB - Biofilms are structured consortia of bacteria embedded in self-produced polymer matrix. Biofilms are resistant to antibiotics, disinfectives and phagocytosis. The persistence of foreign body infections is due to biofilms. Chronic P. aeruginosa lung infection in cystic fibrosis patients is a biofilm. Bacteria in biofilms communicate by means of quorum sensing which activates genes for virulence factors. Biofilms can be prevented by antibiotic prophylaxis or early therapy or by quorum sensing inhibitors which make them susceptible to antibiotics and phagocytosis.

KW - Anti-Bacterial Agents

KW - Antibiotic Prophylaxis

KW - Biofilms

KW - Drug Resistance, Bacterial

KW - Foreign-Body Reaction

KW - Humans

KW - Infection Control

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Quorum Sensing

UR - https://www.scopus.com/pages/publications/38349148687

M3 - Tidsskriftartikel

C2 - 18211783

SN - 0041-5782

VL - 169

SP - 4163

EP - 4166

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 48

ER -

Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing

Abstract

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