Frailty and Cardiovascular Health

Kirstyn James; Yasser Jamil; Manish Kumar; Min J Kwak; Michael G Nanna; Saadia Qazi; Aaron L Troy; Jawad H Butt; Abdulla A Damluji; Daniel E Forman; Ariela R Orkaby

doi:10.1161/JAHA.123.031736

Frailty and Cardiovascular Health

Kirstyn James, Yasser Jamil, Manish Kumar, Min J Kwak, Michael G Nanna, Saadia Qazi, Aaron L Troy, Jawad H Butt, Abdulla A Damluji, Daniel E Forman, Ariela R Orkaby^*

^*Corresponding author for this work

Department of Cardiology

98 Citations (Scopus)

Abstract

The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.

Original language	English
Article number	e031736
Journal	Journal of the American Heart Association
Volume	13
Issue number	15
ISSN	2047-9980
DOIs	https://doi.org/10.1161/JAHA.123.031736
Publication status	Published - 6 Aug 2024

Keywords

Aged
Cardiovascular Diseases/epidemiology
Frail Elderly
Frailty/epidemiology
Geriatric Assessment/methods
Heart Disease Risk Factors
Humans
Incidence
Prognosis
Risk Assessment
Risk Factors
geriatric syndromes
secondary prevention
cardiovascular diseases
frailty
cardiovascular interventions
primary prevention
aging

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10.1161/JAHA.123.031736

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title = "Frailty and Cardiovascular Health",

abstract = "The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.",

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author = "Kirstyn James and Yasser Jamil and Manish Kumar and Kwak, \{Min J\} and Nanna, \{Michael G\} and Saadia Qazi and Troy, \{Aaron L\} and Butt, \{Jawad H\} and Damluji, \{Abdulla A\} and Forman, \{Daniel E\} and Orkaby, \{Ariela R\}",

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doi = "10.1161/JAHA.123.031736",

language = "English",

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AU - James, Kirstyn

AU - Jamil, Yasser

AU - Kumar, Manish

AU - Kwak, Min J

AU - Nanna, Michael G

AU - Qazi, Saadia

AU - Troy, Aaron L

AU - Butt, Jawad H

AU - Damluji, Abdulla A

AU - Forman, Daniel E

AU - Orkaby, Ariela R

PY - 2024/8/6

Y1 - 2024/8/6

N2 - The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.

AB - The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.

KW - Aged

KW - Cardiovascular Diseases/epidemiology

KW - Frail Elderly

KW - Frailty/epidemiology

KW - Geriatric Assessment/methods

KW - Heart Disease Risk Factors

KW - Humans

KW - Incidence

KW - Prognosis

KW - Risk Assessment

KW - Risk Factors

KW - geriatric syndromes

KW - secondary prevention

KW - cardiovascular diseases

KW - frailty

KW - cardiovascular interventions

KW - primary prevention

KW - aging

UR - https://www.scopus.com/pages/publications/85200827485

U2 - 10.1161/JAHA.123.031736

DO - 10.1161/JAHA.123.031736

M3 - Review

C2 - 39056350

SN - 2047-9980

VL - 13

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 15

M1 - e031736

ER -

Frailty and Cardiovascular Health

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Keywords

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