Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Fractures and Osteoporosis in Patients With Diabetes With Charcot Foot

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes. Diabetes Care 2021;44:901-907

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Changes in Albuminuria Predict Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Post Hoc Analysis of the LEADER Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Bariatric surgery and risk of new-onset inflammatory bowel disease: A nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. GLP-1 based therapies and disease course of inflammatory bowel disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. How Common Is the Rare Charcot Foot in Patients With Diabetes?

    Research output: Contribution to journalLetterResearchpeer-review

  4. Developing and validating COVID-19 adverse outcome risk prediction models from a bi-national European cohort of 5594 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: Charcot foot is a serious complication of diabetes, with degeneration of the bones and joints in the foot and ankle. It is unknown whether patients with diabetes with a Charcot foot have an increased risk of osteoporosis and fractures. The aim of this study was to investigate whether patients with diabetes with a Charcot foot have an increased risk of fracture and/or osteoporosis compared with patients with diabetes without Charcot foot.

RESEARCH DESIGN AND METHODS: A Danish register-based, nationwide population-based matched cohort study was conducted. During 1995-2018, we identified 1,602 patients with diabetes with Charcot foot and matched them on sex and date of diagnosis of diabetes with 16,296 patients with diabetes without Charcot foot. We used logistic regression to estimate odds ratios (ORs) with 95% CIs for fracture and osteoporosis. Information about exposure, outcome, and comorbidities was retrieved from the Danish National Patient Register.

RESULTS: Diabetes patients with Charcot foot had higher risk of fractures compared with those without Charcot foot (i.e., ORs for any fracture, lower-leg fracture, foot fracture, and osteoporotic fracture were 1.8 [95% CI 1.6-2.0], 2.4 [2.0-2.8], 2.9 [2.6-3.3], and 1.3 [1.1-1.4], respectively). Furthermore, patients with diabetes with Charcot foot had higher risk of osteoporosis compared with the patients without Charcot foot, with an OR of 1.3 (95% CI 1.1-1.5).

CONCLUSIONS: Patients with diabetes with a Charcot foot have an increased risk of fractures and osteoporosis compared with patients with diabetes without a Charcot foot.

Original languageEnglish
JournalDiabetes Care
Volume44
Issue number9
Pages (from-to)2033-2038
Number of pages6
ISSN1935-5548
DOIs
Publication statusPublished - Sep 2021

ID: 67442416