Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Fractionated free fatty acids and their relation to diabetes status after Roux-en-Y gastric bypass: A cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft-tissue infection

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The influence of fibrillin-1 and physical activity upon tendon tissue morphology and mechanical properties in mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. An exploration of the methods to determine the protein-specific synthesis and breakdown rates in vivo in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Bariatric surgery is associated with near-immediate remission of type 2 diabetes and recently suggested as a treatment for type 2 diabetes. Specifically, Roux-en-Y gastric bypass has been a focus of much research, but still, the mechanisms of action are only partly elucidated. We aim to investigate whether some mechanisms might be mediated by free fatty acids (FFAs). We measured eight fractionated FFAs before and up to 2 years after Roux-en-Y gastric bypass surgery in 207 patients, divided into three groups. One non-diabetic group, one diabetic group with post-operative remission and one diabetic group with persistent diabetes after surgery. Pre- and postoperative levels of fractionated FFAs were compared within and between groups. The sum of the measured FFAs were lower in the group with persistent diabetes, compared to the other groups. The pre-surgery level of linoleic acid in the group with persistent diabetes was significantly lower compared to the other two groups. The levels of fractionated FFAs decreased from pre-surgery to three months after surgery, except for oleic acid and arachidonic acid and for Docosahexaenoic acid (DHA) in the non-diabetic group. The FFAs with decreasing levels from pre-surgery to three months post-surgery are all precursors to oleic acid, arachidonic acid, and DHA, respectively, which may imply a drift, indicating that they need to be sustained at an acceptable level for optimal metabolic function. The fact that the sum of the measured FFAs is lower in the group with persistent diabetes may suggest that this group and the group with diabetes remission represent two distinct types of type 2 diabetes. It is proposed that linoleic acid could be used as a biomarker to determine the plausibility for type 2 diabetes remission after Roux-en-Y gastric bypass surgery.

Original languageEnglish
Article numbere14708
JournalPhysiological Reports
Volume9
Issue number2
Pages (from-to)e14708
ISSN2051-817X
DOIs
Publication statusPublished - Jan 2021

    Research areas

  • free fatty acids, gas chromatography–mass spectrometry, Roux-en-Y Gastric Bypass, type 2 diabetes

ID: 61819471