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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

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New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

Original languageEnglish
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume64
Issue number5
Pages (from-to)198-208
Number of pages11
ISSN0362-4803
DOIs
Publication statusPublished - 15 May 2021

Bibliographical note

© 2020 John Wiley & Sons, Ltd.

    Research areas

  • Oximes

ID: 74080030