Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

Troels E Jeppesen; Jesper B Kristensen; Carsten Behrens; Jacob Madsen; Andreas Kjaer

doi:10.1002/jlcr.3900

Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

Troels E Jeppesen, Jesper B Kristensen, Carsten Behrens, Jacob Madsen, Andreas Kjaer

Department of Clinical Physiology, Nuclear Medicine & PET

Abstract

New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

Original language	English
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	64
Issue number	5
Pages (from-to)	198-208
Number of pages	11
ISSN	0362-4803
DOIs	https://doi.org/10.1002/jlcr.3900
Publication status	Published - 15 May 2021

Keywords

Oximes

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10.1002/jlcr.3900

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abstract = "New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.",

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T1 - Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

AU - Jeppesen, Troels E

AU - Kristensen, Jesper B

AU - Behrens, Carsten

AU - Madsen, Jacob

AU - Kjaer, Andreas

PY - 2021/5/15

Y1 - 2021/5/15

N2 - New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

AB - New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

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DO - 10.1002/jlcr.3900

M3 - Journal article

C2 - 33314295

VL - 64

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

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ER -

Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

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Keywords

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