New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Number of pages||11|
|Publication status||Published - 15 May 2021|