Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Fluorescence or X-ray cholangiography in elective laparoscopic cholecystectomy: a randomized clinical trial

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Differential recurrence after laparoscopic incisional hernia repair: importance of a nationwide registry-based mesh surveillance

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Response to: Meticulous surgical technique cannot be replaced by cholangiography

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Associations between blood cultures after surgery for colorectal cancer and long-term oncological outcomes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Closure of the fascial defect during laparoscopic umbilical hernia repair: a randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Response to: Meticulous surgical technique cannot be replaced by cholangiography

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ovarian removal at or after benign hysterectomy and breast cancer: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Knie- und Hüfttotalendoprothese in 2 Tagen: Das dänische Fast-Track-Modell

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Closure of the fascial defect during laparoscopic umbilical hernia repair: a randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Outpatient total hip or knee arthroplasty in ambulatory surgery center versus arthroplasty ward: a randomized controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Safe laparoscopic cholecystectomy may necessitate biliary imaging, and non-invasive fluorescence cholangiography may have advantages over contrast X-ray cholangiography. This trial compared fluorescence and X-ray cholangiography for visualization of the critical junction between the cystic, common hepatic and common bile ducts.

METHODS: This non-inferiority blinded RCT included patients who had either intraoperative fluorescence cholangiography using 0·05 mg/kg indocyanine green or X-ray cholangiography during elective laparoscopic cholecystectomy.

RESULTS: Between March 2015 and August 2018, a total of 120 patients were randomized (60 in each group). There were no drop-outs and 30-day follow-up data were available for all patients. In intention-to-treat analysis, there was no difference between the fluorescence and X-ray cholangiography groups in ability to visualize the critical junction (49 of 60 versus 51 of 60 respectively; P = 0·230). Fluorescence cholangiography was faster by a few minutes: median 2·0 (range 0·5-5·0) versus 4·8 (1·3-17·6) min (P < 0·001).

CONCLUSION: Fluorescence cholangiography was confirmed to be non-inferior to X-ray cholangiography in visualizing the critical junction during laparoscopic cholecystectomy. Registration number: NCT02344654 ( http://www.clinicaltrials.gov).

Original languageEnglish
JournalThe British journal of surgery
Volume107
Issue number6
Pages (from-to)655-661
Number of pages7
ISSN0007-1323
DOIs
Publication statusPublished - May 2020

ID: 59348006