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Flow-dependent effect of formoterol dry-powder inhaled from the Aerolizer

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The output and size distribution of aerosols from dry powder inhalers are dependent on the flow rate through the device. Therefore, in an in vivo study, we examined the flow-dependency of the effect of formoterol when delivered from a dry powder inhaler, the Aerolizer, in a flow range relevant to schoolchildren. In a preliminary study comprising 126 asthmatic children aged 3-10 yrs, the relationship between age and peak inspiratory flow (PIF) rate through the Aerolizer was determined. Mean PIF was 104 L.min-1 and all children aged > 5 yrs performed a PIF > 60 L.min-1. Sixteen children aged 8-15 yrs with exercise-induced asthma (EIA) took part in the main trial comparing the protective effect of 12 micrograms formoterol inhaled at 60 and 120 L.min-1. The effect from high and low inspiratory flow was judged from the protective effect against EIA 12 h after drug administration. The decrease in forced expiratory volume in one second (FEV1) after exercise was 34% on the placebo day, but only 15% when formoterol was inhaled at the high flow rate. This difference was statistically significant. The decrease in FEV1 was 23% after treatment with formoterol inhaled at the low flow rate, that was not significantly different from placebo or from high-flow formoterol treatment. These clinical findings correspond with the in vitro findings of flow-dependent fine particle mass from the Aerolizer, and corroborate the relationship between fine particle mass of aerosol and clinical effect. The results indicate a flow-dependent effect of formoterol dry powder inhaled from the Aerolizer, within the range of inspiratory flow rate obtainable by school-children. This questions its applicability in children with asthma.

Original languageEnglish
JournalEuropean Respiratory Journal
Volume10
Issue number9
Pages (from-to)2105-9
Number of pages5
ISSN0903-1936
Publication statusPublished - Sep 1997

    Research areas

  • Administration, Inhalation, Adolescent, Asthma, Exercise-Induced, Bronchodilator Agents, Child, Child, Preschool, Cross-Over Studies, Double-Blind Method, Ethanolamines, Female, Forced Expiratory Volume, Humans, Male, Nebulizers and Vaporizers, Powders, Pulmonary Ventilation

ID: 45785355