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Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

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  • Nicola P Bondonno
  • Frederik Dalgaard
  • Cecilie Kyrø
  • Kevin Murray
  • Catherine P Bondonno
  • Joshua R Lewis
  • Kevin D Croft
  • Gunnar Gislason
  • Augustin Scalbert
  • Aedin Cassidy
  • Anne Tjønneland
  • Kim Overvad
  • Jonathan M Hodgson
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Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid intake and mortality outcomes are stronger and more linear in smokers than in non-smokers, as well as in heavy (>20 g/d) vs. low-moderate (<20 g/d) alcohol consumers. These findings highlight the potential to reduce mortality through recommendations to increase intakes of flavonoid-rich foods, particularly in smokers and high alcohol consumers.

Original languageEnglish
JournalNature Communications
Volume10
Issue number1
Pages (from-to)3651
ISSN2041-1723
DOIs
Publication statusPublished - 13 Aug 2019

    Research areas

  • Cardiovascular Diseases/drug therapy, Denmark, Diet, Dietary Supplements/analysis, Female, Flavonoids/administration & dosage, Humans, Life Style, Male, Middle Aged, Neoplasms/drug therapy, Prospective Studies

ID: 59137477