Five-year outcome of cholinergic treatment of Alzheimer's disease: early response predicts prolonged time until nursing home placement, but does not alter life expectancy

A K Wallin, L Gustafson, M Sjögren, C Wattmo, L Minthon

40 Citations (Scopus)

Abstract

Fifty consecutive outpatients with Alzheimer's disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale - cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months -75%, at 12 months -42%, at 24 months -20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at 6 or 12 months was found to predict a prolonged time until nursing home placement. No predictors for a positive treatment response could be identified at baseline.

Original languageEnglish
JournalDementia and Geriatric Cognitive Disorders
Volume18
Issue number2
Pages (from-to)197-206
Number of pages10
ISSN1420-8008
DOIs
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Cholinesterase Inhibitors
  • Dose-Response Relationship, Drug
  • Drug-Induced Liver Injury
  • Female
  • Homes for the Aged
  • Humans
  • Life Expectancy
  • Liver Function Tests
  • Longitudinal Studies
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Neuropsychological Tests
  • Nursing Homes
  • Outcome Assessment (Health Care)
  • Patient Admission
  • Prognosis
  • Psychometrics
  • Survival Analysis
  • Tacrine
  • Treatment Outcome
  • Journal Article
  • Research Support, Non-U.S. Gov't

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