Five-year clinical outcomes of zotarolimus-eluting stents in coronary total occlusions

Henning Kelbæk, Robert W Yeh, Thomas Engstrøm, Franz-Josef Neumann, Patrick W Serruys, Stephan Windecker, Jorge Belardi, Shubin Qiao, Bo Xu, Minglei Liu, Sigmund Silber

Abstract

AIMS: Reports of long-term outcomes of patients treated with drug-eluting stents in total coronary occlusions are limited. We analyzed clinical outcomes of patients treated with the zotarolimus-eluting Resolute stent (R-ZES) implanted in total coronary versus non-occluded lesions.

METHODS AND RESULTS: Patients treated with R-ZES and included in 4 trials (RESOLUTE All Comers, RESOLUTE International, RESOLUTE China RCT, and RESOLUTE China Registry) were pooled and divided in 3 groups: patients with chronic total occlusions (CTO), patients with total occlusions that had occurred recently (rec-TO), and patients without total occlusions (non-TO). Clinical outcomes at 5-years were analyzed. Of 5,487 patients treated with R-ZES in these trials, 8.0% had CTO's, 8.5% rec-TO's and 83.5% non-TO's. Patients had a mean age of 62.8 years, approximately 25% were female and 30% diabetics. TLF was similar in the 3 groups at 5 years (TLF was 13.2%, 12.5% and 13.3% in the CTO, rec-TO and non-TO groups, respectively, p=0.96). Stent thrombosis tended to occur more frequently for rec-TO compared to CTO and non-TO patients (2.6% vs 1.2% and 1.3%, respectively, p=0.11).

CONCLUSIONS: In this large population of patients who had R-ZES implanted, 5-year clinical outcomes were similar whether or not the stents were implanted in total occlusions.

Original languageEnglish
JournalEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Volume16
Issue number16
Pages (from-to)1326-1332
Number of pages7
ISSN1774-024X
DOIs
Publication statusPublished - 19 Mar 2021

Keywords

  • Cardiovascular Agents
  • China/epidemiology
  • Coronary Artery Disease
  • Coronary Occlusion/surgery
  • Drug-Eluting Stents
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Percutaneous Coronary Intervention/adverse effects
  • Prosthesis Design
  • Sirolimus/analogs & derivatives
  • Time Factors
  • Treatment Outcome
  • Drug-eluting stent
  • Stable angina
  • Chronic coronary total occlusion
  • ACS/NSTE-ACS

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