Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mecillinam - Reversion of Resistance and How to Test It

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Neonatal Urine Metabolic Profiling and Development of Childhood Asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  4. A Protocol for Extraction of Infective Viromes Suitable for Metagenomics Sequencing from Low Volume Fecal Samples

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Sensitivity of Multiple Breath Washout to Detect Mild to Moderate Asthma in Adolescence

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: We recently demonstrated that maternal dietary supplementation with fish oil-derived n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) during pregnancy reduces the risk of asthma in the offspring but the mechanisms involved are unknown.

METHODS: Here we investigated potential metabolic mechanisms using untargeted liquid chromatography-mass spectrometry-based metabolomics on 577 plasma samples collected at age 6 months in the offspring of mothers participating in the n-3 LCPUFA randomized controlled trial. First, associations between the n-3 LCPUFA supplementation groups and child metabolite levels were investigated using univariate regression models and data-driven partial least square discriminant analyses (PLS-DA). Second, we analyzed the association between the n-3 LCPUFA metabolomic profile and asthma development using Cox-regression. Third, we conducted mediation analyses to investigate whether the protective effect of n-3 LCPUFA on asthma was mediated via the metabolome.

FINDINGS: The univariate analyses and the PLS-DA showed that maternal fish oil supplementation affected the child's metabolome, especially with lower levels of the n-6 LCPUFA pathway-related metabolites and saturated and monounsaturated long-chain fatty acids-containing compounds, lower levels of metabolites of the tryptophan pathway, and higher levels of metabolites in the tyrosine and glutamic acid pathway. This fish oil-related metabolic profile at age 6 months was significantly associated with a reduced risk of asthma by age 5 and the metabolic profile explained 24% of the observed asthma-protective effect in the mediation analysis.

INTERPRETATION: Several of the observed pathways may be involved in the asthma-protective effect of maternal n-3 LCPUFA supplementation and act as mediators between the intervention and disease development.

FUNDING: COPSAC is funded by private and public research funds all listed on www.copsac.com.

Original languageEnglish
JournalEBioMedicine
Volume46
Pages (from-to)399-410
Number of pages12
DOIs
Publication statusPublished - Aug 2019

Bibliographical note

Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

ID: 57877493