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Finding of IDH1 R132H mutation in histologically non-neoplastic glial tissue changes surgical strategies, a case report

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  1. Telemetric intracranial pressure monitoring in children

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  2. Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results

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  3. The use of 5-ALA to assist complete removal of residual non-enhancing part of childhood medulloblastoma: a case report

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  4. Fronto-cerebellar fiber tractography in pediatric patients following posterior fossa tumor surgery

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  1. Systemic Immune Modulation in Gliomas: Prognostic Value of Plasma IL-6, YKL-40, and Genetic Variation in YKL-40

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  2. WHO grade I meningiomas: classification-tree for prognostic factors of survival

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  3. Organisering af Perifer Nervekirurgi i Danmark

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  4. MYCN amplification drives an aggressive form of spinal ependymoma

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INTRODUCTION: In 2016, the WHO classification of diffuse astrocytoma began to include isocitrate dehydrogenase (IDH) mutation in addition to histology.

RESULTS: We here demonstrate a case where a 14-year-old boy presented with a parietal tumor with no histological evidence of neoplasia but with an IDH1 mutation. Due to the IDH1 R132H mutation, the patient was diagnosed with diffuse astrocytoma WHO grade II and underwent successful gross total resection of this near-eloquently located tumor.

CONCLUSION: This case exemplifies how inclusion of immunohistochemistry in tumor classification alters surgical strategy and might improve accuracy and time to diagnosis.

Original languageEnglish
JournalChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Volume33
Issue number7
Pages (from-to)1217-1220
ISSN0256-7040
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • Journal Article

ID: 49947654