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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Fighting Cancer Using an Oncofetal Glycosaminoglycan-Binding Protein from Malaria Parasites

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DOI

  1. Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria

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  2. Rifins, rosetting, and red blood cells

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  3. Trying to remember: immunological B cell memory to malaria

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  4. Monitoring antifolate resistance in intermittent preventive therapy for malaria

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  5. Of mice and women: rodent models of placental malaria

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  1. Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

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  2. A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine

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  3. Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum

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Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can be detected by the evolutionary refined malaria protein VAR2CSA. Interestingly, using recombinant VAR2CSA to target oncofetal chondroitin sulfate shows promise for novel cancer diagnostics and therapeutics.

Original languageEnglish
JournalTrends in Parasitology
Volume35
Issue number3
Pages (from-to)178-181
Number of pages4
ISSN1471-4922
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • Antigens, Neoplasm/metabolism, Antigens, Protozoan/genetics, Chondroitin Sulfates/metabolism, Neoplasms/diagnosis, Plasmodium/chemistry, Recombinant Proteins/genetics

ID: 59238925