Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes

Claudia Cangemi, Vibe Skov, Michael Kjaer Poulsen, Jonas Amstrup Funder, Waleed O Twal, Mari-Anne Gall, Vibeke E. Hjortdal, Marie Louise Jespersen, Torben A Kruse, Jan Aagard, Hans-Henrik Parving, Steen Knudsen, Poul-Flemming Høilund-Carlsen, Peter Rossing, Jan Erik Henriksen, William Scott Argraves, Lars Melholt Rasmussen

    63 Citations (Scopus)

    Abstract

    Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.
    Original languageEnglish
    JournalClinical Chemistry (Washington, DC)
    Volume57
    Issue number11
    Pages (from-to)1556-65
    Number of pages10
    ISSN0009-9147
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Aged
    • Biological Markers
    • Calcium-Binding Proteins
    • Cardiovascular Diseases
    • Carotid Intima-Media Thickness
    • Case-Control Studies
    • Diabetes Mellitus, Type 2
    • Extracellular Matrix
    • Extracellular Matrix Proteins
    • Female
    • Follow-Up Studies
    • Humans
    • Immunoassay
    • Immunohistochemistry
    • Male
    • Mammary Arteries
    • Middle Aged
    • Oligonucleotide Array Sequence Analysis
    • Predictive Value of Tests
    • Prospective Studies
    • Real-Time Polymerase Chain Reaction

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