Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes

Claudia Cangemi; Vibe Skov; Michael Kjaer Poulsen; Jonas Amstrup Funder; Waleed O Twal; Mari-Anne Gall; Vibeke E. Hjortdal; Marie Louise Jespersen; Torben A Kruse; Jan Aagard; Hans-Henrik Parving; Steen Knudsen; Poul-Flemming Høilund-Carlsen; Peter Rossing; Jan Erik Henriksen; William Scott Argraves; Lars Melholt Rasmussen

doi:10.1373/clinchem.2011.162966

Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes

Claudia Cangemi, Vibe Skov, Michael Kjaer Poulsen, Jonas Amstrup Funder, Waleed O Twal, Mari-Anne Gall, Vibeke E. Hjortdal, Marie Louise Jespersen, Torben A Kruse, Jan Aagard, Hans-Henrik Parving, Steen Knudsen, Poul-Flemming Høilund-Carlsen, Peter Rossing, Jan Erik Henriksen, William Scott Argraves, Lars Melholt Rasmussen

69 Citations (Scopus)

Abstract

Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.

Original language	English
Journal	Clinical Chemistry (Washington, DC)
Volume	57
Issue number	11
Pages (from-to)	1556-65
Number of pages	10
ISSN	0009-9147
DOIs	https://doi.org/10.1373/clinchem.2011.162966
Publication status	Published - 2011

Keywords

Aged
Biological Markers
Calcium-Binding Proteins
Cardiovascular Diseases
Carotid Intima-Media Thickness
Case-Control Studies
Diabetes Mellitus, Type 2
Extracellular Matrix
Extracellular Matrix Proteins
Female
Follow-Up Studies
Humans
Immunoassay
Immunohistochemistry
Male
Mammary Arteries
Middle Aged
Oligonucleotide Array Sequence Analysis
Predictive Value of Tests
Prospective Studies
Real-Time Polymerase Chain Reaction

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10.1373/clinchem.2011.162966

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Cangemi, C., Skov, V., Poulsen, M. K., Funder, J. A., Twal, W. O., Gall, M.-A., Hjortdal, V. E., Jespersen, M. L., Kruse, T. A., Aagard, J., Parving, H.-H., Knudsen, S., Høilund-Carlsen, P.-F., Rossing, P., Henriksen, J. E., Argraves, W. S., & Rasmussen, L. M. (2011). Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes. Clinical Chemistry (Washington, DC), 57(11), 1556-65. https://doi.org/10.1373/clinchem.2011.162966

Cangemi, C, Skov, V, Poulsen, MK, Funder, JA, Twal, WO, Gall, M-A, Hjortdal, VE, Jespersen, ML, Kruse, TA, Aagard, J, Parving, H-H, Knudsen, S, Høilund-Carlsen, P-F, Rossing, P, Henriksen, JE, Argraves, WS & Rasmussen, LM 2011, 'Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes', Clinical Chemistry (Washington, DC), vol. 57, no. 11, pp. 1556-65. https://doi.org/10.1373/clinchem.2011.162966

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title = "Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes",

abstract = "Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.",

keywords = "Aged, Biological Markers, Calcium-Binding Proteins, Cardiovascular Diseases, Carotid Intima-Media Thickness, Case-Control Studies, Diabetes Mellitus, Type 2, Extracellular Matrix, Extracellular Matrix Proteins, Female, Follow-Up Studies, Humans, Immunoassay, Immunohistochemistry, Male, Mammary Arteries, Middle Aged, Oligonucleotide Array Sequence Analysis, Predictive Value of Tests, Prospective Studies, Real-Time Polymerase Chain Reaction",

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doi = "10.1373/clinchem.2011.162966",

language = "English",

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AU - Skov, Vibe

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AU - Funder, Jonas Amstrup

AU - Twal, Waleed O

AU - Gall, Mari-Anne

AU - Hjortdal, Vibeke E.

AU - Jespersen, Marie Louise

AU - Kruse, Torben A

AU - Aagard, Jan

AU - Parving, Hans-Henrik

AU - Knudsen, Steen

AU - Høilund-Carlsen, Poul-Flemming

AU - Rossing, Peter

AU - Henriksen, Jan Erik

AU - Argraves, William Scott

AU - Rasmussen, Lars Melholt

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N2 - Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.

AB - Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.

KW - Aged

KW - Biological Markers

KW - Calcium-Binding Proteins

KW - Cardiovascular Diseases

KW - Carotid Intima-Media Thickness

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 2

KW - Extracellular Matrix

KW - Extracellular Matrix Proteins

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunoassay

KW - Immunohistochemistry

KW - Male

KW - Mammary Arteries

KW - Middle Aged

KW - Oligonucleotide Array Sequence Analysis

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Real-Time Polymerase Chain Reaction

U2 - 10.1373/clinchem.2011.162966

DO - 10.1373/clinchem.2011.162966

M3 - Journal article

C2 - 21926180

SN - 0009-9147

VL - 57

SP - 1556

EP - 1565

JO - Clinical Chemistry (Washington, DC)

JF - Clinical Chemistry (Washington, DC)

IS - 11

ER -

Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes

Abstract

Keywords

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