Fibrinogen concentrate in bleeding patients

Anne Wikkelsø; Jens Lunde; Mathias Johansen; Jakob Stensballe; Jørn Wetterslev; Ann Møller; Arash Afshari

doi:10.1002/14651858.CD008864.pub2

Fibrinogen concentrate in bleeding patients

Anne Wikkelsø, Jens Lunde, Mathias Johansen, Jakob Stensballe, Jørn Wetterslev, Ann Møller, Arash Afshari

150 Citations (Scopus)

Abstract

Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended for bleeding with acquired haemostatic deficiencies in several countries, but evidence is lacking regarding indications, dosing, efficacy and safety.

Original language	English
Journal	Cochrane Database of Systematic Reviews
Volume	8
Pages (from-to)	CD008864
ISSN	1469-493X
DOIs	https://doi.org/10.1002/14651858.CD008864.pub2
Publication status	Published - 2013

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10.1002/14651858.CD008864.pub2

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title = "Fibrinogen concentrate in bleeding patients",

abstract = "Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended for bleeding with acquired haemostatic deficiencies in several countries, but evidence is lacking regarding indications, dosing, efficacy and safety.",

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T1 - Fibrinogen concentrate in bleeding patients

AU - Wikkelsø, Anne

AU - Lunde, Jens

AU - Johansen, Mathias

AU - Stensballe, Jakob

AU - Wetterslev, Jørn

AU - Møller, Ann

AU - Afshari, Arash

PY - 2013

Y1 - 2013

N2 - Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended for bleeding with acquired haemostatic deficiencies in several countries, but evidence is lacking regarding indications, dosing, efficacy and safety.

AB - Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended for bleeding with acquired haemostatic deficiencies in several countries, but evidence is lacking regarding indications, dosing, efficacy and safety.

UR - https://www.scopus.com/pages/publications/84893406145

U2 - 10.1002/14651858.CD008864.pub2

DO - 10.1002/14651858.CD008864.pub2

M3 - Journal article

C2 - 23986527

SN - 1469-493X

VL - 8

SP - CD008864

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

ER -

Fibrinogen concentrate in bleeding patients

Abstract

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