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Fibrinogen: A potential biomarker for predicting disease severity in multiple sclerosis

Research output: Contribution to journalReviewpeer-review

  1. Biomarkers of inflammation and epithelial barrier function in multiple sclerosis

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  2. Increased socioeconomic burden in patients with primary progressive multiple sclerosis: A Danish nationwide population-based study

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  3. Magnetic resonance imaging at baseline and follow-up to differentiate between pediatric monophasic acquired CNS demyelination and MS

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  4. Multiplex assessment of cerebrospinal fluid biomarkers in multiple sclerosis

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  5. Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Neurovascular contact plays no role in trigeminal neuralgia secondary to multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Aggressive multiple sclerosis (2): Treatment

    Research output: Contribution to journalReviewpeer-review

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BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The exact pathogenesis behind the development of MS is unknown. This study aims to elucidate the role of fibrinogen in MS pathology and discuss candidacy as a biomarker for disease management.

METHOD: The method applied is a systematic literature review on the bio-medical database PubMed.

RESULTS: This study found that even though the role of fibrinogen in disease development has been studied considerably, clinical application as a viable biomarker has not yet been achieved conclusively in human studies.

CONCLUSION: Recent evidence points toward fibrinogen and its degradation products playing a possible role in the disease pathogenesis Further research is needed to convincingly evaluate fibrinogen as a practical biomarker for diagnostic use or for assessing disease severity.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Volume46
Pages (from-to)102509
ISSN2211-0348
DOIs
Publication statusPublished - Nov 2020

    Research areas

  • Fibrinogen, Fibrin, Multiple sclerosis, Blood, Cerebrospinal fluid, Diagnosis, Therapeutic use, Prognostic use, Immunology

ID: 61514545