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Fibrin thrombi in deceased donor kidneys: Prevalence and influence on graft function and graft survival in transplanted patients

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@article{392aea1c94f148c5972a75376a87a701,
title = "Fibrin thrombi in deceased donor kidneys: Prevalence and influence on graft function and graft survival in transplanted patients",
abstract = "Fibrin thrombi (FT) are occasionally found in the pre-implantation biopsy of kidneys from deceased donors. The aim of this study was to monitor the prevalence and answer the question whether FT has any impact on future graft function in a Danish patient cohort. We looked for FT in all donor kidney biopsies taken at the time of renal transplantation in a Danish transplantation unit during a 10-year period. Every recipient transplanted with a FT donor kidney (n = 15) were matched with up to five control recipients (n = 69), and graft function and graft survival were assessed. FT was present in 3{\%} of the transplanted donor kidneys. Graft function was reduced in the FT group 6 months after transplantation (median estimated glomerular filtration rate (eGFR): 29 mL/min vs 46 mL/min; p = 0.017), but at 12 months, an apparent difference did not reach statistical significance. More patients were on dialysis in the FT group after 12 months compared with the control group (27{\%} vs 6{\%}; p = 0.049). In conclusion, FT in donor kidney biopsies at time of transplantation is a risk factor for the development of reduced renal function during the first year of transplantation.",
keywords = "Adult, Aged, Female, Fibrin, Graft Survival, Humans, Kidney Transplantation, Male, Middle Aged, Prevalence, Thrombosis, Tissue Donors, Journal Article",
author = "Ditte Hansen and Sara R{\o}rvig and Andersen, {Claus B} and S{\o}rensen, {S{\o}ren Schwartz}",
note = "{\circledC} 2017 APMIS. Published by John Wiley & Sons Ltd.",
year = "2018",
doi = "10.1111/apm.12781",
language = "English",
volume = "126",
pages = "3--8",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",
number = "1",

}

RIS

TY - JOUR

T1 - Fibrin thrombi in deceased donor kidneys

T2 - Prevalence and influence on graft function and graft survival in transplanted patients

AU - Hansen, Ditte

AU - Rørvig, Sara

AU - Andersen, Claus B

AU - Sørensen, Søren Schwartz

N1 - © 2017 APMIS. Published by John Wiley & Sons Ltd.

PY - 2018

Y1 - 2018

N2 - Fibrin thrombi (FT) are occasionally found in the pre-implantation biopsy of kidneys from deceased donors. The aim of this study was to monitor the prevalence and answer the question whether FT has any impact on future graft function in a Danish patient cohort. We looked for FT in all donor kidney biopsies taken at the time of renal transplantation in a Danish transplantation unit during a 10-year period. Every recipient transplanted with a FT donor kidney (n = 15) were matched with up to five control recipients (n = 69), and graft function and graft survival were assessed. FT was present in 3% of the transplanted donor kidneys. Graft function was reduced in the FT group 6 months after transplantation (median estimated glomerular filtration rate (eGFR): 29 mL/min vs 46 mL/min; p = 0.017), but at 12 months, an apparent difference did not reach statistical significance. More patients were on dialysis in the FT group after 12 months compared with the control group (27% vs 6%; p = 0.049). In conclusion, FT in donor kidney biopsies at time of transplantation is a risk factor for the development of reduced renal function during the first year of transplantation.

AB - Fibrin thrombi (FT) are occasionally found in the pre-implantation biopsy of kidneys from deceased donors. The aim of this study was to monitor the prevalence and answer the question whether FT has any impact on future graft function in a Danish patient cohort. We looked for FT in all donor kidney biopsies taken at the time of renal transplantation in a Danish transplantation unit during a 10-year period. Every recipient transplanted with a FT donor kidney (n = 15) were matched with up to five control recipients (n = 69), and graft function and graft survival were assessed. FT was present in 3% of the transplanted donor kidneys. Graft function was reduced in the FT group 6 months after transplantation (median estimated glomerular filtration rate (eGFR): 29 mL/min vs 46 mL/min; p = 0.017), but at 12 months, an apparent difference did not reach statistical significance. More patients were on dialysis in the FT group after 12 months compared with the control group (27% vs 6%; p = 0.049). In conclusion, FT in donor kidney biopsies at time of transplantation is a risk factor for the development of reduced renal function during the first year of transplantation.

KW - Adult

KW - Aged

KW - Female

KW - Fibrin

KW - Graft Survival

KW - Humans

KW - Kidney Transplantation

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Thrombosis

KW - Tissue Donors

KW - Journal Article

U2 - 10.1111/apm.12781

DO - 10.1111/apm.12781

M3 - Journal article

VL - 126

SP - 3

EP - 8

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

IS - 1

ER -

ID: 52664612