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Fetal Heart Defects and Measures of Cerebral Size

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Harvard

Lauridsen, MH, Uldbjerg, N, Petersen, OB, Vestergaard, EM, Matthiesen, NB, Henriksen, TB, Østergaard, JR & Hjortdal, VE 2019, 'Fetal Heart Defects and Measures of Cerebral Size', The Journal of pediatrics, vol. 210, pp. 146-153. https://doi.org/10.1016/j.jpeds.2019.02.042

APA

Lauridsen, M. H., Uldbjerg, N., Petersen, O. B., Vestergaard, E. M., Matthiesen, N. B., Henriksen, T. B., Østergaard, J. R., & Hjortdal, V. E. (2019). Fetal Heart Defects and Measures of Cerebral Size. The Journal of pediatrics, 210, 146-153. https://doi.org/10.1016/j.jpeds.2019.02.042

CBE

Lauridsen MH, Uldbjerg N, Petersen OB, Vestergaard EM, Matthiesen NB, Henriksen TB, Østergaard JR, Hjortdal VE. 2019. Fetal Heart Defects and Measures of Cerebral Size. The Journal of pediatrics. 210:146-153. https://doi.org/10.1016/j.jpeds.2019.02.042

MLA

Vancouver

Lauridsen MH, Uldbjerg N, Petersen OB, Vestergaard EM, Matthiesen NB, Henriksen TB et al. Fetal Heart Defects and Measures of Cerebral Size. The Journal of pediatrics. 2019 Jul;210:146-153. https://doi.org/10.1016/j.jpeds.2019.02.042

Author

Lauridsen, Mette Høj ; Uldbjerg, Niels ; Petersen, Olav Bjørn ; Vestergaard, Else Marie ; Matthiesen, Niels Bjerregaard ; Henriksen, Tine Brink ; Østergaard, John Rosendahl ; Hjortdal, Vibeke Elisabeth. / Fetal Heart Defects and Measures of Cerebral Size. In: The Journal of pediatrics. 2019 ; Vol. 210. pp. 146-153.

Bibtex

@article{526de767a7a34d5b9b1db7b7713f4a99,
title = "Fetal Heart Defects and Measures of Cerebral Size",
abstract = "OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.",
keywords = "Birth Weight, Case-Control Studies, Cephalometry, Cohort Studies, Denmark/epidemiology, Female, Fetal Weight, Heart Defects, Congenital/epidemiology, Humans, Infant, Newborn, Placenta/anatomy & histology, Pregnancy, Regression Analysis, Ultrasonography, Prenatal",
author = "Lauridsen, {Mette H{\o}j} and Niels Uldbjerg and Petersen, {Olav Bj{\o}rn} and Vestergaard, {Else Marie} and Matthiesen, {Niels Bjerregaard} and Henriksen, {Tine Brink} and {\O}stergaard, {John Rosendahl} and Hjortdal, {Vibeke Elisabeth}",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = jul,
doi = "10.1016/j.jpeds.2019.02.042",
language = "English",
volume = "210",
pages = "146--153",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby, Inc",

}

RIS

TY - JOUR

T1 - Fetal Heart Defects and Measures of Cerebral Size

AU - Lauridsen, Mette Høj

AU - Uldbjerg, Niels

AU - Petersen, Olav Bjørn

AU - Vestergaard, Else Marie

AU - Matthiesen, Niels Bjerregaard

AU - Henriksen, Tine Brink

AU - Østergaard, John Rosendahl

AU - Hjortdal, Vibeke Elisabeth

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/7

Y1 - 2019/7

N2 - OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.

AB - OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.

KW - Birth Weight

KW - Case-Control Studies

KW - Cephalometry

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Female

KW - Fetal Weight

KW - Heart Defects, Congenital/epidemiology

KW - Humans

KW - Infant, Newborn

KW - Placenta/anatomy & histology

KW - Pregnancy

KW - Regression Analysis

KW - Ultrasonography, Prenatal

U2 - 10.1016/j.jpeds.2019.02.042

DO - 10.1016/j.jpeds.2019.02.042

M3 - Journal article

C2 - 30961987

VL - 210

SP - 146

EP - 153

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -

ID: 60424688