Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

FeNO and Exercise Testing in Children at Risk of Asthma

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Allergy Development in Adulthood: An Occupational Cohort Study of the Manufacturing of Industrial Enzymes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Role and Impact of Chronic Cough in Individuals with Asthma From the General Population

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sensitivity of Multiple Breath Washout to Detect Mild to Moderate Asthma in Adolescence

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy

    Research output: Contribution to journalReviewResearchpeer-review

  5. Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Antibiotic exposure in infancy and development of BMI and body composition in childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Exercise testing is the gold standard for diagnosing exercise-induced bronchoconstriction in children, but requires considerable cooperation and medical resources. Therefore, fraction of exhaled nitric oxide (FeNO) has been proposed as a tool to predict the need for exercise testing.

OBJECTIVE: The objective of this study was to investigate the relationship between FeNO, exercise test results, and a history of respiratory symptoms during exercise in children at risk of asthma.

METHODS: FeNO measurement, exercise testing, and interview about respiratory symptoms during exercise were completed in 224 seven-year-old children from the at-risk Copenhagen Prospective Studies on Asthma in Childhood2000 birth cohort. The associations between FeNO, exercise test results, and reported respiratory symptoms during exercise were analyzed adjusting for gender, respiratory infections, and inhaled corticosteroid treatment. The associations were also analyzed stratified by asthma and atopic status.

RESULTS: Of the 224 children, 28 (13%) had an established asthma diagnosis and 58 (26%) had a positive exercise test (≥15% drop in forced expiratory volume in 1 second [FEV1] from baseline). FeNO and bronchial obstruction after exercise were linearly associated with a doubling of FeNO corresponding to a 2.4% drop in FEV1 (95% confidence interval, 0.8-4.1; P < .01). However, a receiver operating characteristic curve analysis showed that the best cutoff of FeNO for predicting exercise test outcome among children who reported respiratory symptoms during exercise was 17 ppb, which only had 74% negative predictive value. There was no association between FeNO and reported respiratory symptoms during exercise (odds ratio = 1.3 [0.8-1.9]; P = .29) or reported symptoms during exercise and exercise test results (odds ratio = 1.0 [1.0-1.1]; P = .12).

CONCLUSIONS: A history of respiratory symptoms during exercise was not associated with either elevated FeNO or a positive exercise test in children at risk of asthma. FeNO and exercise test results were linearly associated traits, but FeNO could not reliably be used dichotomized to predict the need of exercise testing.

Original languageEnglish
Article numbere2
JournalThe journal of allergy and clinical immunology. In practice
Volume6
Issue number3
Pages (from-to)855-862
Number of pages8
ISSN2213-2198
DOIs
Publication statusPublished - May 2018

    Research areas

  • Journal Article

ID: 52650099