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The Capital Region of Denmark - a part of Copenhagen University Hospital
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FENO and AHR mannitol in patients referred to an out-of-hospital asthma clinic: a real-life study

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Abstract Objective: Ongoing airway inflammation measured by fractional exhaled nitric oxide (FENO) and airway hyperresponsiveness (AHR) to mannitol are associated in selected asthma patients, but no evidence exists of this association in unselected asthma patients. The aim was to investigate the association between FENO and AHR to mannitol in unselected individuals with possible asthma. Methods: A real-life study on patients with possible asthma referred to a specialized asthma clinic. Data on asthma history, FEV1, FENO, atopy, smoking, treatment and AHR to mannitol were collected. Results: In 217 unselected patients with symptoms suggestive of asthma, FENO and response to mannitol were tested. Of the 141 who underwent both tests, 32 (23%) had FENO > 25 ppb, and 58 (41%) had AHR to mannitol. A significant association between high FENO and AHR was found (p 
Original languageEnglish
JournalThe Journal of asthma : official journal of the Association for the Care of Asthma
Volume51
Issue number4
Pages (from-to)411-416
Number of pages5
ISSN0277-0903
DOIs
Publication statusPublished - 23 Jan 2014

ID: 42813150