Femoral artery recanalisation with percutaneous angioplasty and segmentally enclosed plasminogen activator

B Jørgensen, K H Tønnesen, J Bülow, J D Nielsen, M Jørgensen, P Holstein, E Andersen

21 Citations (Scopus)

Abstract

To establish whether re-occlusion of the femoral artery could be prevented, in 6 consecutive patients undergoing percutaneous transluminal angioplasty (PTA) for superficial femoral artery occlusion the recanalised segment was isolated, with a 7-French double-balloon catheter. 5 mg recombined human tissue-type plasminogen activator (rt-PA) and 1000 IU heparin were then infused into the enclosed space for 30 minutes, followed by intravenous heparin for 24 hours. At 10 and 30 days all 6 patients had evidence of recanalisation and remission of symptoms. Mean ankle-arm pressure index improved by 72% at 24 hours, by 118% at 10 days, and by 103% at 30 days after the procedure. No patients had major complications. Treatment of superficial femoral artery occlusions by PTA with rt-PA and intravenous heparin seems to prevent rethrombosis.
Original languageEnglish
JournalLancet
Volume1
Issue number8647
Pages (from-to)1106-8
Number of pages3
ISSN0140-6736
Publication statusPublished - 20 May 1989

Keywords

  • Aged
  • Angioplasty, Balloon
  • Arterial Occlusive Diseases
  • Catheters, Indwelling
  • Combined Modality Therapy
  • Femoral Artery
  • Fibrinogen
  • Heparin
  • Humans
  • Middle Aged
  • Plasminogen Activators
  • Recombinant Proteins
  • Recurrence
  • Thrombosis
  • Time Factors
  • Vascular Patency

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